CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
嵌合抗原受体（CAR）T 细胞治疗原发性脑肿瘤的进展
英文原题：Advances in Chimeric Antigen Receptor (CAR) T-Cell Therapies for the Treatment of Primary Brain Tumors.
查看英文原题
Advances in Chimeric Antigen Receptor (CAR) T-Cell Therapies for the Treatment of Primary Brain Tumors.
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中文摘要
免疫疗法彻底改变了癌症患者的治疗。多种克服癌症免疫抑制并增强肿瘤靶向免疫反应的策略已用于临床，但尚未给脑肿瘤患者带来突破性获益。过继性细胞疗法利用患者自身免疫细胞产生定向抗肿瘤活性，是有望改善儿童和成人原发性脑肿瘤治疗的新兴技术。本文综述嵌合抗原受体（CAR）T 细胞疗法治疗侵袭性原发性脑肿瘤的最新进展，包括胶质母细胞瘤和 H3 K27M 突变型弥漫性中线胶质瘤。我们重点介绍当前治疗方法和令人鼓舞的研究数据，并阐述神经肿瘤学领域开发及实施这类疗法面临的关键挑战。
展开英文摘要原文
Immunotherapy has revolutionized the care of cancer patients. A diverse set of strategies to overcome cancer immunosuppression and enhance the tumor-directed immune response are in clinical use, but have not achieved transformative benefits for brain tumor patients. Adoptive cell therapies, which employ a patient's own immune cells to generate directed anti-tumor activity, are emerging technologies that hold promise to improve the treatment of primary brain tumors in children and adults.
Here, we review recent advances in chimeric antigen receptor (CAR) T-cell therapies for the treatment of aggressive primary brain tumors, including glioblastoma and diffuse midline glioma, H3 K27M-mutant.
We highlight current approaches, discuss encouraging investigational data, and describe key challenges in the development and implementation of these types of therapies in the neuro-oncology setting.
论文信息
- 作者
- Mount CW、Gonzalez Castro LN
- 第一作者单位
- Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.United States
- 通讯作者单位
- Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.United States
- 文献类型
- 综述
- 期刊
- Antibodies (Basel, Switzerland)2022 Apr 27
- 原文标识
- PubMed 35645204 · DOI 10.3390/antib11020031
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →