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CAR-T 细胞治疗慢性淋巴细胞白血病:成功与不足

英文原题:CAR T Cell Therapy for Chronic Lymphocytic Leukemia: Successes and Shortcomings.

查看英文原题

CAR T Cell Therapy for Chronic Lymphocytic Leukemia: Successes and Shortcomings.

PubMed 2022/05/18(内容时间) Curr Oncol Q2 · IF 3.6(JCR 2025)

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中文摘要

CAR-T(CAR-T)细胞疗法在B细胞白血病和淋巴瘤中取得了显著成功,使其被纳入这些疾病的治疗方案。与其他恶性肿瘤相比,CAR-T 细胞疗法在慢性淋巴细胞白血病(CLL)患者中的成功率较低。在这篇综述中,我们讨论了已发表的关于CLL的CAR-T 细胞治疗结果、可能的失败机制以及预期的发展方向。

展开英文摘要原文

Chimeric antigen receptor T (CAR T) cell therapy achieved remarkable success in B-cell leukemia and lymphoma which led to its incorporation in treatment protocols for these diseases. CAR T cell therapy for chronic lymphocytic leukemia (CLL) patients showed less success compared to other malignant tumors. In this review, we discuss the published results regarding CAR T cell therapy of CLL, possible mechanisms of failures and expected developments.

论文信息

作者
Todorovic Z、Todorovic D、Markovic V、Ladjevac N、Zdravkovic N、Djurdjevic P、Arsenijevic N、Milovanovic M
第一作者单位
Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
通讯作者单位
Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
文献类型
综述 · 非美国政府资助研究
期刊
Current oncology (Toronto, Ont.)2022 May 18
原文标识
PubMed 35621683 · DOI 10.3390/curroncol29050293