更正：B7-H3 CAR-T 细胞清除肝内胆管癌并诱导持久应答
Correction: B7-H3 CAR T cells eradicate intrahepatic cholangiocarcinoma and induce durable response.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肝内胆管癌中基质 TIL（肿瘤浸润淋巴细胞）的预后价值：一项基于人群的研究
英文原题：The prognostic value of stromal tumor-infiltrating lymphocytes in intrahepatic cholangiocarcinoma: a population-based study.
查看英文原题
The prognostic value of stromal tumor-infiltrating lymphocytes in intrahepatic cholangiocarcinoma: a population-based study.
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研究概要
我们的数据提示，对于完全切除后 ICC 患者的 PFS 和 OS 预测，间质 TILs 发挥重要作用。
研究思路结论见上方概要
目的
我们评估TIL（肿瘤浸润淋巴细胞）（TILs）对接受完全切除术的肝内胆管癌（ICC）患者总生存期（OS）和无进展生存期（PFS）的预测价值。
方法
本研究纳入了68例可切除的ICC患者。我们通过用苏木精和伊红（HE）染色手术切除的ICC患者切片，研究了间质TIL密度并对其进行评分。通过检索临床和随访记录，获取了ICC患者的临床数据和预后。
结果
间质TIL阴性状态是OS不良（HR = 0.41，95% CI 0.20-0.83，p = .01）和PFS不良（HR = 0.47，95% CI 0.23-0.97，p = .04）的独立预测因素。低间质TIL密度与高水平CA125（p = .03）和高水平CA19-9（p < .01）相关。高水平CA19-9（p = .05）、高分化（p = .02）、大直径（p = .05）、胆管/血管癌栓阳性（p = .03）和卫星结节阳性（p = .02）是间质TIL阴性状态患者发生肿瘤的倾向。
展开英文摘要原文
OBJECTIVE
We assess the predictive value impacted by tumor-infiltrating lymphocytes (TILs) for overall survival (OS) and progression-free survival (PFS) in patients with intrahepatic cholangiocarcinoma (ICC) undergoing complete resection.
METHODS
Sixty-eight patients with resectable ICC were included in this study. We studied stromal TIL density and scored it by staining sections from surgically resected ICC patients with hematoxylin and eosin (HE). The clinical data and prognosis of patients with ICC were obtained by searching clinical and follow-up records.
RESULTS
A stromal TIL negative status was a predictor of poor OS (HR = 0.41, 95% CI 0.20-0.83, p = .01) and poor PFS (HR = 0.47, 95% CI 0.23-0.97, p = .04) independently. Low stromal TIL density was associated with high levels of CA125 ( p = .03) and CA19-9 ( p < .01). The high level of CA19-9 ( p = .05), high differentiation ( p = .02), a large diameter ( p = .05), a positive bile duct/vascular cancer embolus ( p = .03) and positive satellite nodules ( p = .02) were tendencies to develop tumors for patients with a negative status of stromal TIL.
CONCLUSION
Our data prompt for the prediction of the PFS and OS of patients with ICC after complete resection, stromal TILs play an important role.
论文信息
- 作者
- Qiang Z、Dai K、He Y、Yang Z、Tao L、Zhang H、Yu H
- 单位
- Department of Hepatobiliary Surgery, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.China
- 期刊
- Scandinavian journal of gastroenterology2022 Aug
- 原文标识
- PubMed 35522155 · DOI 10.1080/00365521.2022.2055972