CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：CRISPR/Cas9 application in cancer therapy: a pioneering genome editing tool.
CRISPR/Cas9 application in cancer therapy: a pioneering genome editing tool.
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20世纪70年代基因工程的进展带来了基因组编辑技术的范式转变。成簇规律间隔短回文重复序列/CRISPR相关蛋白9（CRISPR/Cas9）系统是一种靶向和修饰基因组中特定DNA序列的灵活手段。目前正在癌症生物学和肿瘤学中研究CRISPR/Cas9的若干应用，以提供强有力的位点特异性基因编辑，从而增强其生物学和临床用途。CRISPR的灵活性和易用性使得几乎任何所需的改变都能以前所未有的效率和低于先前方法的成本迅速实现。此外，CRISPR/Cas9技术最近已被应用于提高嵌合抗原受体（CAR）-T细胞疗法的安全性和有效性，并克服肿瘤细胞对化疗和放疗等常规治疗的耐药性。本综述总结了CRISPR/Cas9在癌症治疗中的应用。我们还讨论了当前的障碍并思考了这方面的未来可能性。
The progress of genetic engineering in the 1970s brought about a paradigm shift in genome editing technology. The clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) system is a flexible means to target and modify particular DNA sequences in the genome. Several applications of CRISPR/Cas9 are presently being studied in cancer biology and oncology to provide vigorous site-specific gene editing to enhance its biological and clinical uses.
CRISPR's flexibility and ease of use have enabled the prompt achievement of almost any preferred alteration with greater efficiency and lower cost than preceding modalities. Also, CRISPR/Cas9 technology has recently been applied to improve the safety and efficacy of chimeric antigen receptor (CAR)-T cell therapies and defeat tumor cell resistance to conventional treatments such as chemotherapy and radiotherapy. The current review summarizes the application of CRISPR/Cas9 in cancer therapy.
We also discuss the present obstacles and contemplate future possibilities in this context.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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