γδ T 细胞调节小细胞肺癌中的抗肿瘤免疫
γδ T cells modulate anti-tumor immunity in small cell lung cancer.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
非常规 T 细胞在癌症中的双重性
英文原题：The duplexity of unconventional T cells in cancer.
查看英文原题
The duplexity of unconventional T cells in cancer.
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中文摘要
与常规 T 细胞相比，非常规 T 细胞及其在癌症中的作用研究较少，但近期的研究结果表明，这些细胞在癌症进展和抑制中均发挥重要作用。在此，我们简要综述三种非常规 T 细胞谱系的双重作用：γδ T 细胞、MAIT 细胞和 NKT 细胞。使用小鼠癌症模型的研究表明，这非常规三者在肿瘤演化过程中如何与癌症上皮细胞及其他免疫细胞群体相互作用。这些报道突出了多种可能用于癌症免疫治疗的潜在干预途径。
展开英文摘要原文
Unconventional T cells and their involvement in cancer are understudied in comparison to conventional T cells, but recent findings indicate that these cells play important roles in both cancer progression and inhibition.
Here, we briefly review the dichotomous role of three unconventional T cell lineages: γδ T cells, MAIT cells and NKT cells. Studies using mouse models of cancer show how this unconventional trilogy interacts with cancer epithelial cells and other immune cell populations during tumour evolution. These reports highlight various potential avenues for therapeutic intervention that may be exploited for cancer immunotherapy.
论文信息
- 作者
- Lawrence M、Wiesheu R、Coffelt SB
- 第一作者单位
- Cancer Research UK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, UK.United Kingdom
- 通讯作者单位
- Cancer Research UK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, UK. Electronic address: Seth.Coffelt@glasgow.ac.uk.United Kingdom
- 文献类型
- 非美国政府资助研究
- 期刊
- The international journal of biochemistry & cell biology2022 May
- 原文标识
- PubMed 35447350 · DOI 10.1016/j.biocel.2022.106213