CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
小汗腺汗孔癌与汗孔瘤肿瘤微环境中 UV 诱导的局部免疫抑制
英文原题：UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma.
查看英文原题
UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma.
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中文摘要
小汗腺汗孔癌（EPC）是一种罕见的皮肤恶性附件肿瘤。部分 EPC 由其良性对应病变汗孔瘤（EP）发展而来，慢性光照暴露和免疫抑制被认为在恶性转化中发挥作用。
然而，慢性光照暴露对 EPC 和 EP 微环境的影响尚未被研究。尽管TIL（肿瘤浸润淋巴细胞）（TILs）和三级淋巴结构（TLSs）的临床相关性已在多种肿瘤中得到确立，但其在 EPC 和 EP 中的分布及意义仍知之甚少。
我们通过 CD3、CD4、CD8、CD20 免疫组化，在 10 例 EPC 和 49 例 EP 的队列中表征了 TILs 和 TLSs 的分布。随后我们使用日光性弹性组织变性分级对样本进行分类，分析紫外线（UV）损伤对 TIL 密度的影响。观察到 UV 损伤与 TIL 密度之间呈负相关（CD4 r = -0.286，p = 0.04。CD8 r = -0.305，p = 0.033）。EPC 与 EP 之间的 TIL 密度未发现显著差异。TLS 稀少，EPC 中存在率为 10%，EP 中为 8.3%。
结果表明，UV 对 EPC 和 EP 的微环境具有免疫抑制作用。
展开英文摘要原文
Eccrine porocarcinoma (EPC) is a rare malignant adnexal tumour of the skin. Part of EPCs develop from their benign counterpart, poroma (EP), with chronic light exposure and immunosuppression hypothesized to play a role in the malignant transformation.
However, the impact of chronic light exposure on the microenvironment of EPCs and EPs has not been investigated yet. Although the clinical relevance of tumour infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) has been established in various tumours, their distribution and significance in EPCs and EPs is still poorly understood.
We characterized the distribution of TILs and TLSs using CD3, CD4, CD8, CD20 immunohistochemistry in a cohort of 10 EPCs and 49 EPs.
We then classified our samples using solar-elastosis grading, analyzing the influence of ultraviolet (UV) damage on TIL density. A negative correlation between UV damage and TIL density was observed (CD4 r = -0. 286, p = 0. 04. CD8 r = -0. 305, p = 0. 033). No significant difference in TIL density was found between EPCs and EPs. TLS was scarse with the presence rate 10% in EPCs and 8. 3% in EPs. The results suggest that UV has an immunosuppressive effect on the microenvironment of EPCs and EPs.
论文信息
- 作者
- Puttonen M、Isola J、Ylinen O、Böhling T、Koljonen V、Sihto H
- 单位
- Department of Pathology, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland. maya.puttonen@helsinki.fi.Finland
- 文献类型
- 非美国政府资助研究
- 期刊
- Scientific reports2022 Apr 1
- 原文标识
- PubMed 35365704 · DOI 10.1038/s41598-022-09490-5
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