工程化益生菌用于肿瘤靶向联合化学免疫治疗
Engineered probiotics for tumor-targeted combination chemoimmunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
儿童及年轻成人实体瘤的过继细胞治疗：现状与未来方向
英文原题：Adoptive Cell Therapy in Pediatric and Young Adult Solid Tumors: Current Status and Future Directions.
查看英文原题
Adoptive Cell Therapy in Pediatric and Young Adult Solid Tumors: Current Status and Future Directions.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
新型过继细胞疗法尚未在儿童和青年实体瘤治疗中充分实现其潜力。本文讨论相关策略和初步结果，包括基于T细胞、NK细胞和髓系细胞的疗法。尽管这些方法均显示出早期潜力，仍面临挑战，包括细胞向肿瘤迁移能力差，以及多种免疫抑制机制构成的恶劣肿瘤微环境，导致细胞治疗发生耗竭。随后，本文探讨旨在应对这些挑战的新策略，包括正在开展或筹备中的新型临床试验。
展开英文摘要原文
Advances from novel adoptive cellular therapies have yet to be fully realized for the treatment of children and young adults with solid tumors. This review discusses the strategies and preliminary results, including T-cell, NK-cell and myeloid cell-based therapies. While each of these approaches have shown some early promise, there remain challenges. These include poor trafficking to the tumor as well as a hostile tumor microenvironment with numerous immunosuppressive mechanisms which result in exhaustion of cellular therapies.
We then turn our attention to new strategies proposed to address these challenges including novel clinical trials that are ongoing and in development.
论文信息
- 作者
- Ligon JA、Wessel KM、Shah NN、Glod J
- 单位
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.United States
- 文献类型
- 美国 NIH 院内研究 · 综述
- 期刊
- Frontiers in immunology2022
- 原文标识
- PubMed 35273619 · DOI 10.3389/fimmu.2022.846346
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →