CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
NK 细胞大颗粒淋巴细胞增多症中贫血对促红细胞生成素的持续应答：简要病例报告
英文原题：Sustained response to erythropoietin for anemia in NK-cell large granular lymphocytosis: A brief case report.
查看英文原题
Sustained response to erythropoietin for anemia in NK-cell large granular lymphocytosis: A brief case report.
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中文摘要
大颗粒淋巴细胞白血病（LGL）是一种罕见淋巴增殖性疾病，约85%病例涉及T细胞谱系，15%涉及NK细胞谱系。多数患者在病程某一阶段需要治疗临床症状，主要是血细胞减少。免疫抑制治疗是LGL治疗的基础，但免疫抑制失败后的最佳后续方案尚无共识。本文报告一名73岁男性LGL相关血细胞减少病例；患者对免疫抑制治疗无应答，接受辅助性促红细胞生成素α（EPO）后出现显著应答。本病例提示，对难治性LGL病例，在免疫抑制治疗基础上联合EPO可能带来治疗获益。
展开英文摘要原文
Large granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder that involves the T-cell lineage in around 85% of cases and NK-cell lineage in 15%. Most patients require treatment at some point of their disease trajectory to address clinical symptomatology largely pertaining to cytopenia. While immunosuppression represents the backbone of LGL therapy, there is no consensus on the best next line following failure of immunosuppression.
Here we present a case of LGL-associated cytopenia in a 73-year-old male refractory to immunosuppression, treated with adjunct erythropoietin alpha (EPO) with a marked response.
Our case suggests that EPO therapy may provide therapeutic benefit in refractory LGL cases when used in conjunction with immunosuppressive therapy.
论文信息
- 作者
- Kwaramba T、Lewis B、Burks B、Ruiz B、Iyer SP、Safa F
- 第一作者单位
- Department of Medicine, Tulane University, New Orleans, LA United States.United States
- 通讯作者单位
- Section of Hematology and Medical Oncology, Department of Medicine, Tulane University, New Orleans, LA United States.United States
- 文献类型
- 病例报告
- 期刊
- Leukemia research reports2022
- 原文标识
- PubMed 35242524 · DOI 10.1016/j.lrr.2022.100292
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