CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
食管癌肉瘤中 PD-L1 表达与瘤内 CD8(+) T 淋巴细胞
英文原题：PD-L1 Expression and Intra-Tumoral CD8(+) T Lymphocytes in Esophageal Carcinosarcoma.
查看英文原题
PD-L1 Expression and Intra-Tumoral CD8(+) T Lymphocytes in Esophageal Carcinosarcoma.
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中文摘要
我们在19例食管癌肉瘤（ECS）患者中检测了PD-L1和瘤内CD8 + T淋巴细胞（CD8 + TIL）。这些患者的中位随访期为43个月，3年和5年生存率分别为78.9%和63.2%。在肉瘤成分（SC）中，PD-L1与CD8 + TIL之间未观察到统计学显著相关性（r = -0.262，p = 0.279），在上皮癌成分（EC）中亦无显著相关性（r = 0.055，p = 0.824）。本研究首次检测了ECS中的免疫标志物。PD-L1在SC中高表达，并与较差预后相关。
展开英文摘要原文
We detected PD-L1 and intra-tumoral CD8 + T lymphocytes (CD8 + TIL) in 19 patients with esophageal carcinosarcoma (ECS). The median follow-up period of these patients was 43 months, and the three- and five-year survival rates were 78. 9 and 63. 2%, respectively. No statistically significant correlation was observed between PD-L1 and CD8 + TIL in sarcomatous components(SC) ( r = -0. 262, p = 0. 279) and epithelial carcinomatous (EC) ( r = 0. 055, p = 0. 824).
This study examined the immunological markers in ECS for the first time. PD-L1 is highly expressed in the SC and is associated with a poorer prognosis.
论文信息
- 作者
- Chen S、Zhu J、Wang P、Wan D、Cui X、Xu Y、Zhang X、Yin H
- 第一作者单位
- Department of Radiation Oncology, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, Nantong, China.China
- 通讯作者单位
- Department of Radiation Oncology, Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China.China
- 期刊
- Cancer investigation2022 Apr
- 原文标识
- PubMed 35100066 · DOI 10.1080/07357907.2022.2029474