工程化益生菌用于肿瘤靶向联合化学免疫治疗
Engineered probiotics for tumor-targeted combination chemoimmunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
改造肿瘤基质力学以改善 T 细胞治疗
英文原题：Engineering tumor stromal mechanics for improved T cell therapy.
查看英文原题
Engineering tumor stromal mechanics for improved T cell therapy.
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中文摘要
包括工程化T细胞受体（TCR）疗法和嵌合抗原受体（CAR）T细胞疗法在内的过继细胞治疗（ACT），目前处于癌症免疫治疗前沿。然而，其治疗实体瘤的疗效尚未得到证实。实体瘤周围的纤维化间质被认为是削弱并抑制工程化T细胞的主要屏障。本文综述近期关于肿瘤间质抑制T细胞机制的研究发现，特别关注间质力学特性的影响；同时讨论用于解析间质力学因素抑制T细胞机制的工程学方法。最后，展望通过改变肿瘤间质纤维化来提高T细胞治疗效果的策略。
展开英文摘要原文
Adoptive cellular therapies (ACT), including the engineered T cell receptor (TCR) therapy and chimeric antigen receptor (CAR) T Cell Therapy, are currently at the forefront of cancer immunotherapy.
However, their efficacy for the treatment of solid tumors has not been confirmed. The fibrotic stroma surrounding the solid tumor has been suggested as the main barrier in the disarmament and suppression of the engineered T cells. In this review, we will discuss the recent findings on the mechanism of T cell suppression by the tumor stroma with a special emphasis on the effect of stromal mechanics.
We will also discuss the engineering approaches used to dissect the mechanism of the T cell suppression by the stromal mechanical factors.
Finally, we will provide a future outlook on the strategies to improve the efficacy of T cell therapy through altering the tumor stromal fibrosis.
论文信息
- 作者
- Ying L、Yazdani M、Koya R、Zhao R
- 第一作者单位
- Department of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.United States
- 通讯作者单位
- Department of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA. Electronic address: rgzhao@buffalo.edu.United States
- 文献类型
- 美国 NIH 资助研究 · 非美国政府资助研究 · 综述
- 期刊
- Biochimica et biophysica acta. General subjects2022 Apr
- 原文标识
- PubMed 35077823 · DOI 10.1016/j.bbagen.2022.130095