为肝细胞癌武装 GPC3 CAR-T 细胞：多少才足够，下一步是什么？
Armouring GPC3 CAR T cells for hepatocellular carcinoma: how much is enough and what comes next?
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
甲胎蛋白在肝细胞癌中的全景：我们身在何处？
英文原题：The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?
查看英文原题
The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?
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中文摘要
肝细胞癌（HCC）是最常见的原发性肝癌，也是肝硬化患者死亡的重要原因。早期诊断困难及肿瘤异质性阻碍了有效治疗，对晚期HCC尤为如此。肝移植（LT）被认为是HCC的最佳治疗方式。尽管不断有新的生物标志物被提出，60多年前发现的甲胎蛋白（AFP）仍是应用最广泛的指标。近年来，研究者寄望于利用AFP的免疫原性开发新疗法，例如AFP疫苗和AFP特异性过继T细胞转移（ACT）。本文综述AFP在HCC诊断和预后评估中的表现及其与分子分型的相关性，并介绍AFP在肝移植中的作用。最后，重点讨论两种HCC免疫疗法——AFP疫苗和ACT——的作用机制及应用前景。总体而言，本文阐述了AFP在HCC中的普遍应用，同时指出相关争议和未来研究的新方向。
展开英文摘要原文
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has been acknowledged as a leading cause of death among cirrhosis patients. Difficulties in early diagnosis and heterogeneity are obstacles to effective treatment, especially for advanced HCC. Liver transplantation (LT) is considered the best therapy for HCC.
Although many biomarkers are being proposed, alpha-fetoprotein (AFP), which was identified over 60 years ago, remains the most utilized. Recently, much hope has been placed in the immunogenicity of AFP to develop novel therapies, such as AFP vaccines and AFP-specific adoptive T-cell transfer (ACT). This review summarizes the performance of AFP as a biomarker for HCC diagnosis and prognosis, as well as its correlation with molecular classes.
In addition, the role of AFP in LT is also described. Finally, we highlight the mechanism and application prospects of two immune therapies (AFP vaccine and ACT) for HCC. In general, our review points out the prevalence of AFP in HCC, accompanied by some controversies and novel directions for future research.
论文信息
- 作者
- Hu X、Chen R、Wei Q、Xu X
- 单位
- Department of Hepatobiliary and Pancreatic Surgery, The Center for Integrated Oncology and Precision Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.China
- 文献类型
- 非美国政府资助研究 · 综述
- 期刊
- International journal of biological sciences2022
- 原文标识
- PubMed 35002508 · DOI 10.7150/ijbs.64537
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