tisagenlecleucel 与 lisocabtagene maraleucel 在复发/难治性大 B 细胞淋巴瘤成人患者中的疗效比较：一项间接治疗比较

This study compared overall survival (OS), progression-free survival (PFS), complete response rate (CRR), and overall response rate (ORR) of tisagenlecleucel (tisa-cel) and lisocabtagene maraleucel (liso-cel) in relapsed or refractory large B-cell lymphomas (r/r LBCL). Using matching-adjusted indirect comparison (MAIC), individual patient-level data from JULIET (tisa-cel) were weighted to match the patient population in TRANSCEND (liso-cel). The main analysis compared infused JULIET patients ( N = 106) with the TRANSCEND efficacy-evaluable set (EES) ( N = 256 [infused]).

After adjustment, OS, PFS, and the CRR were comparable between tisa-cel and liso-cel EES patients. The estimated adjusted 2-year OS, 2-year PFS, ORR, and CRR were 45. 6, 38. 2, 62. 9, and 47. 7%, respectively, for tisa-cel vs. 43. 8, 42. 1, 72. 7, and 53. 1% for liso-cel. A scenario analysis compared JULIET patients to the TRANSCEND primary analysis set (PAS) ( N = 133). ORR was significantly higher in the TRANSCEND PAS compared with matched JULIET patients, but no significant differences in CRR were observed.