CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
接受基于慢病毒的 CAR-T 细胞治疗患者中的人类免疫缺陷病毒检测假阳性结果：病例报告、文献综述与建议
英文原题：False-Positive Human Immunodeficiency Virus Test Results in Patients Receiving Lentivirus-Based Chimeric Antigen Receptor T-Cell Therapy: Case Report, Review of the Literature, and Proposed Recommendations.
查看英文原题
False-Positive Human Immunodeficiency Virus Test Results in Patients Receiving Lentivirus-Based Chimeric Antigen Receptor T-Cell Therapy: Case Report, Review of the Literature, and Proposed Recommendations.
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中文摘要
已有新发报告显示，接受嵌合抗原受体（CAR）T细胞治疗的患者出现HIV核酸检测（NAT）假阳性。我们报告一例66岁女性，患有原发性难治性IIIA期双打击高级别B细胞淋巴瘤，在接受第三代自我失活研究性慢病毒载体CAR-T 细胞治疗后，我们检测到HIV-1 NAT假阳性结果。我们回顾了HIV-1 NAT的当前科学进展，发现所有已报告的假阳性病例均发生在基于慢病毒的CAR-T 细胞治疗以及使用针对5'LTR基因组区域的FDA批准平台进行检测的情况下。在此，我们为接受该治疗模式的患者提供HIV诊断检测建议。管理该患者群体的临床医生应意识到这些治疗药物与常用HIV-1 NAT检测之间的交叉反应性。
展开英文摘要原文
There are emerging reports of false-positive HIV nucleic acid testing (NAT) in patients who have received chimeric antigen receptor (CAR) T-cell therapies.
We present a case of a 66-year-old-woman with primary-refractory stage IIIA double-hit high-grade B-cell lymphoma, in whom we detected false-positive HIV-1 NAT results after receipt of a third-generation self-inactivating investigational lentivirus-based CAR T-cell therapy.
We reviewed the current state of the science on HIV-1 NAT and found that all reported false-positive cases have occurred in the setting of lentivirus-based CAR T-cell therapy and testing with FDA-approved platforms targeting the 5'LTR genomic region.
Herein, we offer recommendations for HIV diagnostic testing in patients undergoing this mode of therapy. Clinicians managing this patient population should be aware of cross-reactivity between these therapeutic agents and commonly used HIV-1 NAT assays.
论文信息
- 作者
- Villalba JA、Maus MV、Frigault MJ、Zaffini R、Gandhi RT、Rosenberg ES、Siedner MJ
- 第一作者单位
- Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.United States
- 通讯作者单位
- Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.United States
- 文献类型
- 病例报告 · 综述
- 期刊
- The Journal of infectious diseases2022 Jun 1
- 原文标识
- PubMed 34927686 · DOI 10.1093/infdis/jiab605