CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Humanized Patient-Derived Xenograft Models of Ovarian Cancer.
Humanized Patient-Derived Xenograft Models of Ovarian Cancer.
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癌症的体内建模是测试新型治疗策略以推进患者护理的关键步骤。在此，我们描述了如何开发一种人源化患者来源异种移植（PDX）卵巢癌模型，该模型利用原位移植的患者卵巢肿瘤，并自体转移扩增的肿瘤浸润T细胞（TILs），作为一种可用于在体内测试免疫调节治疗药物的模型。
In vivo modeling of cancer is a critical step in testing novel therapeutic strategies to advance patient care.
Here we describe how to develop a humanized patient-derived xenograft (PDX) model of ovarian cancer that uses orthotopically transplanted patient ovarian tumors with autologous transfer of expanded tumor infiltrating T cells (TILs) as a model that can be utilized to test immunomodulating therapeutics in vivo.
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