CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
鞘脂和溶血磷脂酸对肿瘤免疫微环境的调控
英文原题：Regulation of Tumor Immune Microenvironment by Sphingolipids and Lysophosphatidic Acid.
查看英文原题
Regulation of Tumor Immune Microenvironment by Sphingolipids and Lysophosphatidic Acid.
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中文摘要
肿瘤微环境（TME）由癌细胞与基质成分相互作用构成，这些基质成分包括细胞外基质、血液和淋巴网络、成纤维细胞、脂肪细胞以及免疫系统细胞。此外，以肿瘤浸润免疫细胞（TIIC）为主要代表的肿瘤免疫微环境在癌症治疗和患者预后中发挥着重要作用。事实上，已知肿瘤微环境内高密度的TIIC与多种癌症类型的较好结局相关。为此，两种生物活性脂质分子——溶血磷脂酸（LPA）和1-磷酸鞘氨醇（S1P）——调控免疫细胞向TME的归巢。在本综述中，我们将揭示LPA和S1P信号在肿瘤免疫环境中的作用，并重点介绍该领域的最新进展。
展开英文摘要原文
The tumor microenvironment (TME) consists of cancer cells that interact with stromal components such as the extracellular matrix, blood, and lymphatic networks, fibroblasts, adipocytes, and the cells of the immune system.
Further, the tumor immune microenvironment, majorly represented by the tumor-infiltrating immune cells (TIIC), plays an important role in cancer therapeutics and patient prognosis. In fact, a high density of TIICs within the tumor microenvironment is known to be associated with better outcomes in several types of cancers.
Towards this, two bioactive lipid molecules, lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), regulate the homing of immune cells to the TME. In the present review, we will uncover the role of LPA and S1P signaling in the tumor immune environment, highlighting the latest progress in this field.
论文信息
- 作者
- Vishwakarma S、Arya N、Kumar A
- 单位
- Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Saket Nagar, Bhopal 462020, India.India
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Current drug targets2022
- 原文标识
- PubMed 34879798 · DOI 10.2174/1389450122666211208111833