不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗后的疾病特异性结局
英文原题：Disease-specific outcomes after chimeric antigen receptor T-cell therapy.
查看英文原题
Disease-specific outcomes after chimeric antigen receptor T-cell therapy.
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中文摘要
我们比较了在临床试验中接受相同CD19嵌合抗原受体（CAR）T细胞治疗的不同适应症B细胞恶性肿瘤患者的结局，包括B细胞急性淋巴细胞白血病（B-ALL）、弥漫性大B细胞淋巴瘤（DLBCL）、套细胞淋巴瘤（MCL）和滤泡性淋巴瘤（FL）。我们发现，对于同一种CAR-T 细胞，疗效和毒性因疾病而异。总体而言，我们发现与DLBCL相比，FL、MCL和B-ALL中的原发性耐药率较低。与更具侵袭性的疾病（如B-ALL、DLBCL和MCL）相比，FL中的急性毒性（细胞因子释放综合征和ICANS）似乎显著较轻。这些观察结果表明，每种B细胞恶性肿瘤都具有特定的生物学特征，其与CAR-T 细胞治疗的相互作用可能不同。因此，CAR-T 细胞可能需要根据B细胞恶性肿瘤的类型进行不同的定制，以优化其疗效和安全性。
展开英文摘要原文
We compared outcomes of patients with B-cell malignancies treated in clinical trials with the same CD19 chimeric antigen receptor (CAR) T-cells across different indications, including B-cell acute lymphoblastic leukaemia (B-ALL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL) and follicular lymphoma (FL).
We found that for a given CAR T-cell, efficacy and toxicity varied depending on the disease.
Overall, we found a low rate of primary resistance in FL, MCL and B-ALL compared with DLBCL. Acute toxicities (cytokine release syndrome and ICANS) appeared to be significantly less severe in FL compared with more aggressive diseases, such as B-ALL, DLBCL and MCL. These observations suggest that each B-cell malignancy harbours specific biology, which may interact differently with CAR T-cell therapy.
Thus, CAR T-cells may be tailored differently depending on the type of B-cell malignancy to optimise their efficacy and safety.
论文信息
- 作者
- Lemoine J、Vic S、Houot R
- 第一作者单位
- AP-HP, Department of Hematology, Université de Paris, Paris, France.France
- 通讯作者单位
- Department of Hematology, CHU de Rennes, Université de Rennes, Rennes, France; INSERM U1236, Rennes, France. Electronic address: roch.houot@gmail.com.France
- 期刊
- European journal of cancer (Oxford, England : 1990)2022 Jan
- 原文标识
- PubMed 34865943 · DOI 10.1016/j.ejca.2021.10.022