CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
为抗肿瘤免疫工程化 T 细胞记忆
英文原题：Engineering T cell memory for antitumor immunity.
查看英文原题
Engineering T cell memory for antitumor immunity.
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中文摘要
T细胞生长因子白细胞介素（IL）-2的癌症治疗受到低缓解率和毒性的限制。多种蛋白质工程策略试图改善IL-2治疗，通常通过增强IL-2受体（IL-2R）结合来实现。有趣的是，Mo等人表明，IL-2R部分激动剂可能通过改变T细胞分化来显著改善IL-2应答。
展开英文摘要原文
Cancer therapy with the T cell growth factor interleukin (IL)-2 is limited by low response rates and toxicity. Multiple protein engineering strategies have attempted to improve IL-2 therapy, typically through enhanced IL-2 receptor (IL-2R) binding. Intriguingly, Mo et al. show that an IL-2R partial agonist may dramatically improve IL-2 responses by altering T cell differentiation.
论文信息
- 作者
- Bhuiyan AM、Dougan M
- 第一作者单位
- Albert Einstein College of Medicine, Bronx, NY, USA.United States
- 通讯作者单位
- Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: mldougan@partners.org.United States
- 文献类型
- 美国 NIH 资助研究 · 非美国政府资助研究
- 期刊
- Trends in pharmacological sciences2022 Jan
- 原文标识
- PubMed 34785086 · DOI 10.1016/j.tips.2021.11.003