人类实体瘤中新抗原及同源 TCR 的灵敏鉴定

The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen.

Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.