CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
过继转移肿瘤特异性 Th9 细胞可清除表达异质性抗原的肿瘤细胞
英文原题：Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells.
查看英文原题
Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells.
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中文摘要
在本期Cancer Cell中，Xue等人证明，过继转移肿瘤特异性Th9细胞可以通过直接杀伤和旁观者效应根除含有抗原丢失变异细胞（ALVs）的已建立肿瘤，这些效应由肿瘤内细胞外ATP（eATP）积累介导，促进单核细胞浸润并刺激IFNα/β产生。
展开英文摘要原文
In this issue of Cancer Cell, Xue et al. demonstrate that adoptive transfer of tumor-specific Th9 cells can eradicate established tumors containing antigen-loss-variant cells (ALVs) through both direct killing and bystander effects mediated by intratumoral accumulation of extracellular ATP (eATP) that promotes monocyte infiltration and stimulation of IFNα/β production.
论文信息
- 作者
- Sek K、Chan CW、Beavis PA、Darcy PK
- 第一作者单位
- Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville 3010, Australia.Australia
- 通讯作者单位
- Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3000, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville 3010, Australia; Department of Pathology, University of Melbourne, Parkville 3010, Australia; Department of Immunology, Monash University, Clayton, Australia. Electronic address: phil.darcy@petermac.org.Australia
- 文献类型
- 非美国政府资助研究 · 评论
- 期刊
- Cancer cell2021 Dec 13
- 原文标识
- PubMed 34739846 · DOI 10.1016/j.ccell.2021.10.013