CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
DNA 损伤反应通路的改变：癌症免疫治疗的生物标志物和治疗策略
英文原题：Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy.
查看英文原题
Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy.
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中文摘要
基因组不稳定性仍然是癌症的一个使能特征，并促进恶性转化。DNA损伤应答（DDR）通路的改变导致基因组不稳定性，产生新抗原，上调程序性死亡配体1（PD-L1）的表达，并与环鸟苷酸-腺苷酸合成酶-干扰素基因刺激因子（cGAS-STING）等信号通路相互作用。在此，我们综述了DDR通路的基础知识、DDR改变诱导基因组不稳定性的机制、DDR改变对免疫系统的影响，以及DDR改变作为癌症免疫治疗中生物标志物和治疗靶点的潜在应用。
展开英文摘要原文
Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response (DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1 (PD-L1) and interact with signaling such as cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling.
Here, we review the basic knowledge of DDR pathways, mechanisms of genomic instability induced by DDR alterations, impacts of DDR alterations on immune system, and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy.
论文信息
- 作者
- Jiang M、Jia K、Wang L、Li W、Chen B、Liu Y、Wang H、Zhao S
- 单位
- Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China.China
- 文献类型
- 综述
- 期刊
- Acta pharmaceutica Sinica. B2021 Oct
- 原文标识
- PubMed 34729299 · DOI 10.1016/j.apsb.2021.01.003
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