CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤微环境中的外泌体：从生物学到临床应用
英文原题：Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications.
查看英文原题
Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications.
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中文摘要
癌症是全球最重要的健康问题之一，也是全球第二大死因。尽管肿瘤学取得了进展，但癌症异质性仍然是治疗面临的挑战。这是因为肿瘤微环境（TME）内癌症与非癌细胞之间由外泌体介导的串扰促进了癌症所有标志性特征的获得，并导致癌症干细胞（CSC）的形成，而CSC对一系列抗癌药物表现出耐药性。因此，本综述旨在总结TME来源的外泌体在癌症生物学中的作用，并探讨间充质干细胞来源的外泌体作为癌症治疗的临床潜力，讨论无细胞疗法用于癌症治疗的未来前景以及需要克服的挑战。
展开英文摘要原文
Cancer is one of the most important health problems and the second leading cause of death worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to therapeutics. This is because the exosome-mediated crosstalk between cancer and non-cancer cells within the tumor microenvironment (TME) contributes to the acquisition of all hallmarks of cancer and leads to the formation of cancer stem cells (CSCs), which exhibit resistance to a range of anticancer drugs.
Thus, this review aims to summarize the role of TME-derived exosomes in cancer biology and explore the clinical potential of mesenchymal stem-cell-derived exosomes as a cancer treatment, discussing future prospects of cell-free therapy for cancer treatment and challenges to be overcome.
论文信息
- 作者
- da Costa VR、Araldi RP、Vigerelli H、D'Ámelio F、Mendes TB、Gonzaga V、Policíquio B、Colozza-Gama GA
- 单位
- Programa de Pós-Graduação em Biologia Estrutural e Funcional, Escola Paulista de Medicina (EPM), Federal University of São Paulo (UNIFES), São Paulo 04039-032, Brazil.Brazil
- 文献类型
- 非美国政府资助研究 · 综述
- 期刊
- Cells2021 Oct 1
- 原文标识
- PubMed 34685596 · DOI 10.3390/cells10102617
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →