CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Gene editing to enhance the efficacy of cancer cell therapies.
Gene editing to enhance the efficacy of cancer cell therapies.
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过继性T细胞疗法已显示出令人瞩目的活性信号，但通过提高T细胞效力并降低这些产品生产相关成本与工作量的技术，其临床影响力有望进一步增强。基因编辑平台正在该领域开展研究，旨在：(1) 通过敲除抑制免疫应答的分子来增强免疫细胞效力；(2) 将基因载荷递送至精确的基因组位置，从而通过利用生理性启动子、增强子和抑制子来提高安全性和/或改善基因表达谱；(3) 通过防止同种异体反应性和免疫排斥来实现现货型疗法。本综述讨论了在人类T细胞和过继性T细胞疗法背景下研究最为深入的基因编辑方法，总结了其当前状态及近期转化潜力。
Adoptive T cell therapies have shown impressive signals of activity, but their clinical impact could be enhanced by technologies to increase T cell potency and diminish the cost and labor involved in manufacturing these products.
Gene editing platforms are under study in this arena to (1) enhance immune cell potency by knocking out molecules that inhibit immune responses; (2) deliver genetic payloads into precise genomic locations and thereby enhance safety and/or improve the gene expression profile by leveraging physiologic promoters, enhancers, and repressors; and (3) enable off-the-shelf therapies by preventing alloreactivity and immune rejection.
This review discusses gene editing approaches that have been the best studied in the context of human T cells and adoptive T cell therapies, summarizing their current status and near-term potential for translation.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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