为肝细胞癌武装 GPC3 CAR-T 细胞：多少才足够，下一步是什么？
Armouring GPC3 CAR T cells for hepatocellular carcinoma: how much is enough and what comes next?
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
体外 3D 肝肿瘤微环境模型用于免疫细胞治疗优化
英文原题：In vitro 3D liver tumor microenvironment models for immune cell therapy optimization.
查看英文原题
In vitro 3D liver tumor microenvironment models for immune cell therapy optimization.
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中文摘要
尽管在诊断和治疗方面取得了进展，肝癌每年仍在全球导致超过1800万人死亡，这迫切需要新的策略来建立该疾病的模型并改进当前的治疗选择。人类癌症的体外肿瘤模型不断演进，它们代表着重要的筛选工具。然而，极大地需要提高这些体外模型的生理相关性和可靠性，以满足当今研究需求，从而更好地理解癌症进展以及疾病不同阶段的治疗选择。本综述描述了肝细胞癌的微环境特征，并阐述了当前用于对抗该疾病的免疫治疗策略。此外，我们呈现了近期收集的2D和3D体外肝癌模型，并更详细地讨论了下一代能够重现肿瘤微环境复杂性的体外系统。
展开英文摘要原文
Despite diagnostic and therapeutic advances, liver cancer kills more than 18 million people every year worldwide, urging new strategies to model the disease and to improve the current therapeutic options. In vitro tumor models of human cancer continue to evolve, and they represent an important screening tool.
However, there is a tremendous need to improve the physiological relevance and reliability of these in vitro models to fulfill today's research requirements for better understanding of cancer progression and treatment options at different stages of the disease. This review describes the hepatocellular carcinoma microenvironmental characteristics and illustrates the current immunotherapy strategy to fight the disease.
Moreover, we present a recent collection of 2D and 3D in vitro liver cancer models and address the next generation of in vitro systems recapitulating the tumor microenvironment complexity in more detail.
论文信息
- 作者
- Lam M、Reales-Calderon JA、Ow JR、Adriani G、Pavesi A
- 单位
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology, and Research (ASTAR), Singapore, Singapore.Singapore
- 文献类型
- 综述
- 期刊
- APL bioengineering2021 Dec
- 原文标识
- PubMed 34632251 · DOI 10.1063/5.0057773
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