不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
以神经淋巴瘤病累及多对颅神经为首发表现的原发性结外 NK/T 细胞淋巴瘤：一例病例报告
英文原题：Primary Extranodal NK/T-Cell Lymphoma Presenting as Neurolymphomatosis Involving Multiple Cranial Nerves: A Case Report.
查看英文原题
Primary Extranodal NK/T-Cell Lymphoma Presenting as Neurolymphomatosis Involving Multiple Cranial Nerves: A Case Report.
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中文摘要
神经淋巴瘤病（NL）是一种由淋巴瘤或白血病浸润神经引起的罕见疾病，表现为神经病。大多数情况下，NL与B系非霍奇金淋巴瘤（NHL）相关，仅偶尔与T系或NK系NHL同时发生。结外NK/T细胞淋巴瘤（ENKTL）相关的NL极为罕见，除我们的病例外，英文文献中仅描述了9例。NL的诊断具有挑战性，因为该实体可模仿更常见病因的神经病，且可能难以获得充分的活检。及时诊断需要高度怀疑，尤其是对于无血液系统恶性肿瘤病史的患者。我们扩展了一例独特的NL病例，该病例仅累及颅神经和马尾神经根，作为ENKTL的初始表现，并将我们的发现置于先前报道的NK/T系NL病例框架内。
展开英文摘要原文
Neurolymphomatosis (NL) is a rare condition caused by the lymphomatous or leukemic infiltration of nerves and manifests as neuropathy. Most often, NL is associated with B-lineage non-Hodgkin lymphoma (NHL) and only infrequently occurs in conjunction with T- or NK-lineage NHL.
Extranodal NK/T-cell lymphoma (ENKTL)-associated NL is exceedingly unusual, with only 9 cases described in the English language literature, in addition to our case. Diagnosis of NL is challenging, as the entity can mimic neuropathies of more common etiologies, and an adequate biopsy may be difficult to obtain. Timely diagnosis demands a high index of suspicion, especially for patients without a history of hematologic malignancy.
We expand upon a unique case of NL exclusively involving cranial nerves and cauda equina nerve roots, as the initial manifestation of ENKTL, and contextualize our findings within the framework of previously reported NK/T-lineage NL cases.
论文信息
- 作者
- Ghosh S、Azzi J、Chan AM、Nael K、Renteria AS、Steinberg A、Petersen BE
- 第一作者单位
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.United States
- 通讯作者单位
- Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.United States
- 文献类型
- 病例报告
- 期刊
- Acta haematologica2022
- 原文标识
- PubMed 34569490 · DOI 10.1159/000518797