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儿童癌症研究的最新进展

英文原题:Recent Advances in Pediatric Cancer Research.

查看英文原题

Recent Advances in Pediatric Cancer Research.

PubMed 2021/09/24(内容时间) Cancer Res Q1 · IF 22.6(JCR 2025)

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中文摘要

在过去几年中,儿童癌症领域的发展势头发生了转变,这带来了新的、令人振奋的发现,其意义超越了儿童恶性肿瘤本身。在此,我们介绍儿童癌症研究关键方面的当前状况。我们重点关注疾病的遗传和表观遗传驱动因素、不同儿童癌症的细胞起源、疾病模型、肿瘤微环境以及细胞免疫疗法。

展开英文摘要原文

Over the past few years, the field of pediatric cancer has experienced a shift in momentum, and this has led to new and exciting findings that have relevance beyond pediatric malignancies.

Here we present the current status of key aspects of pediatric cancer research.

We have focused on genetic and epigenetic drivers of disease, cellular origins of different pediatric cancers, disease models, the tumor microenvironment, and cellular immunotherapies.

论文信息

作者
McEachron TA、Helman LJ
单位
Pediatric Oncology Branch, NCI, Bethesda, Maryland. Troy.McEachron@NIH.gov.United States
文献类型
美国 NIH 院内研究 · 综述
期刊
Cancer research2021 Dec 1
原文标识
PubMed 34561271 · DOI 10.1158/0008-5472.CAN-21-1191