CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤免疫微环境中的细胞外囊泡
英文原题：Extracellular vesicles in the tumor immune microenvironment.
查看英文原题
Extracellular vesicles in the tumor immune microenvironment.
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中文摘要
近几十年来，细胞外囊泡（EVs）作为细胞间通讯的主要介质，参与多种重要的生理和病理过程，已引起广泛关注。它们几乎由所有细胞类型分泌，携带蛋白质、脂质和核酸等生物活性物质，这些物质可以从宿主细胞传递至受体细胞，从而引发受体细胞表型和功能的改变。近期证据表明，EVs 在重塑肿瘤免疫微环境（TIME）中发挥重要作用。来源于肿瘤细胞和免疫细胞的 EVs 在近端和远端位点介导相互通讯，这决定了肿瘤命运和抗肿瘤治疗疗效。在本综述中，我们总结了目前对 EVs 及其在重塑 TIME 和调控肿瘤特异性免疫中作用的认识。我们主要讨论 TIME 中肿瘤细胞与肿瘤浸润免疫细胞通过 EVs 递送实现的相互调控。我们还描述了当前研究的局限性并讨论了进一步研究的方向。
展开英文摘要原文
Extracellular vesicles (EVs) have gained significant attention in recent decades as major mediators of intercellular communication that are involved in various essential physiological and pathological processes. They are secreted by almost all cell types and carry bioactive materials, such as proteins, lipids and nucleic acids, that can be transmitted from host cells to recipient cells, thereby eliciting phenotypic and functional alterations in the recipient cells.
Recent evidence shows that EVs play essential roles in remodeling the tumor immune microenvironment (TIME). EVs derived from tumor cells and immune cells mediate mutual communication at proximal and distal sites, which determines tumor fate and antitumor therapeutic effectiveness. In this review, the current understanding of EVs and their roles in remodeling the TIME and modulating tumor-specific immunity are summarized.
We mainly discuss the mutual regulation between tumor cells and tumor-infiltrating immune cells through the delivery of EVs in the TIME.
We also describe the limitations of current studies and discuss directions for further research.
论文信息
- 作者
- Hou PP、Chen HZ
- 第一作者单位
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, China.China
- 通讯作者单位
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, China. Electronic address: Chenhz@xmu.edu.cn.China
- 文献类型
- 非美国政府资助研究 · 综述
- 期刊
- Cancer letters2021 Sep 28
- 原文标识
- PubMed 34082025 · DOI 10.1016/j.canlet.2021.05.032