BE-CAR33——一种用于急性髓系白血病的「现货型」碱基编辑 CAR33 T 细胞疗法——的 I 期可行性试验
A phase 1 feasibility trial of BE-CAR33, an "off-the-shelf" base-edited CAR33 T cell therapy for acute myeloid leukemia.
DISEASE HUB
FOR TREATMENT
现在就能报名的(招募中)排在最前,共 2 项。同一状态内中国中心优先。信息来自 ClinicalTrials.gov 与 CDE 公开登记。能否入组、费用与可及性,以登记原文和主治医生判断为准。
FOR RESEARCH
A phase 1 feasibility trial of BE-CAR33, an "off-the-shelf" base-edited CAR33 T cell therapy for acute myeloid leukemia.
Anti-CD7 fratricide-resistant chimeric antigen receptor T cells for relapsed/refractory acute myeloid leukemia.
Targeting CD38 with bispecific antibody XmAb 18968 in patients with relapsed/refractory acute myeloid leukemia and T-cell acute lymphoblastic leukemia
Correction: CD7 chimeric antigen receptor T cells in patients with relapsed or refractory CD7-positive acute myeloid leukemia.
TA-TMA occurring after sequential CD7 CAR-T cell therapy and allogeneic hematopoietic stem cell transplantation: a case report.
CD7 chimeric antigen receptor T cells in patients with relapsed or refractory CD7-positive acute myeloid leukemia.
Overcoming disease refractoriness through CD7-targeting CAR T cells in acute myeloid leukemia.
Nanobody-based naturally selected CD7-targeted CAR-T therapy for acute myeloid leukemia.
CD7 CAR-T cells eliminate chronic myeloid leukemia stem cells specifically and effectively.
本研究针对当前 CML 治疗的关键局限,即 TKIs 无法消除 LSCs,并证实了 CD7 与 LSC 生存之间的相关性,以及 CD7 CAR-T 对 CML 的靶向潜力。本研究表明,使用 CD7 CAR-T 细胞特异性消除 LSCs 在体外是有效且合理的,这为靶向 LSC 的 CML 治疗提供了实验证据,并为后续体内和转化研究奠定了基础。
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