不依赖抗 CD137 激动剂抗体且临床可行的软组织肉瘤与骨肉瘤 TIL(肿瘤浸润淋巴细胞)制备
Anti-CD137 agonist antibody-independent and clinically feasible preparation of tumor-infiltrating lymphocytes from soft tissue sarcoma and osteosarcom
使用 CD3/CD28 激活剂替代无法获得的抗 CD137 激动剂来制备抗肿瘤 TIL 是可行的。
DISEASE HUB
FOR TREATMENT
按「中国试验优先 → 正在招募 → 更新更近」排序。信息来自 ClinicalTrials.gov 与 CDE 公开登记。能否入组、费用与可及性,以登记原文和主治医生判断为准。
FOR RESEARCH
Anti-CD137 agonist antibody-independent and clinically feasible preparation of tumor-infiltrating lymphocytes from soft tissue sarcoma and osteosarcom
使用 CD3/CD28 激活剂替代无法获得的抗 CD137 激动剂来制备抗肿瘤 TIL 是可行的。
LTX-315 and adoptive cell therapy using tumor-infiltrating lymphocytes generate tumor specific T cells in patients with metastatic soft tissue sarcoma
这项初步研究证明,将LTX-315与过继性T细胞疗法联合使用是可行的,并且这种治疗可以诱导全身免疫反应,从而使原本疾病进展的肉瘤患者病情稳定。
Immune infiltrates in patients with localised high-risk soft tissue sarcoma treated with neoadjuvant chemotherapy without or with regional hyperthermi
术前治疗将基线时的非炎症性肿瘤重编程为炎症性肿瘤。治疗后的免疫浸润可预测临床结局。联合区域热疗可启动肿瘤微环境,从而在高危软组织肉瘤中增强抗肿瘤免疫活性。
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