为实体瘤中 T 细胞受体工程 T 细胞疗法注入新活力:拓展精准治疗普适性的增强策略
Breathing new life into T-cell receptor-engineered T-cell therapy in solid tumors: enhancing strategies to expand the universality of precision therap
过继性 T 细胞转移疗法(ACT)显著推动了肿瘤免疫治疗的进展。
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Breathing new life into T-cell receptor-engineered T-cell therapy in solid tumors: enhancing strategies to expand the universality of precision therap
过继性 T 细胞转移疗法(ACT)显著推动了肿瘤免疫治疗的进展。
Cell-Type-Tailored Hydrogels for Adoptive Cell Therapy in Cancer.
水凝胶赋能的过继细胞疗法(ACT)为改善实体瘤的细胞免疫治疗提供了一种局部且可控的策略。
CAR-T and TIL therapies in solid tumors: barriers, clinical lessons, and convergent solutions.
2024年lifileucel的获批标志着肿瘤学领域的一个重要里程碑,成为首个获批用于实体瘤的细胞疗法。
Tightly bound T-cell clusters: A new class of hyper-effector tumor killers.
这些见解将T细胞聚类重新定位为有效抗肿瘤免疫的基本决定因素。
Going with the Flow: Circulating Tumor-Reactive Lymphocytes Stream into Cancer Therapy.
过继性细胞治疗(ACT),迄今最典型的代表是CAR-T 细胞、工程化 T 细胞受体和TIL(肿瘤浸润淋巴细胞)治疗,已成为癌症免疫治疗中一种具有变革性的方法。
The trinity of T cell engagement: navigating the molecular and clinical landscape of CAR-T, TILs, and TCEs in the war against cancer.
癌症免疫疗法的出现从根本上重构了肿瘤学范式,从直接靶向肿瘤细胞动力学的药物转向赋能宿主免疫系统识别和清除恶性肿瘤的策略。
Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours.
过继性T细胞疗法治疗实体瘤受到肿瘤细胞凋亡抵抗机制和细胞外免疫抑制性肿瘤微环境的限制。
Rapid and direct discovery of functional tumor specific neoantigens by high resolution mass spectrometry and novel algorithm prediction.
尽管免疫细胞疗法已经改变了癌症治疗格局,但与NHL和MM等血液系统恶性肿瘤相比,在实体瘤中取得同等成功仍然是一项重大挑战。
Targeting T-Cells for Cancer Treatment: Current Clinical Strategies and Challenges.
对靶向肿瘤细胞的免疫应答进行调节已被证明是一种成功的癌症治疗策略。
Beyond the CAR T Cells: TIL Therapy for Solid Tumors.
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