CAR T 细胞:改善儿童肿瘤结局所缺失的一环?
CAR T cells: the missing piece needed to improve outcomes for children with cancer?
B 细胞急性淋巴细胞白血病 (B-ALL) 是儿童期最常见的癌症。
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CAR T cells: the missing piece needed to improve outcomes for children with cancer?
B 细胞急性淋巴细胞白血病 (B-ALL) 是儿童期最常见的癌症。
Beyond Hematology-Current Insights into Chimeric Antigen Receptor (CAR) T-Cell Therapy for Skin and Connective Tissue Disorders.
嵌合抗原受体(CAR)T 细胞疗法是现代免疫治疗的一项重大进展。
Advances in CAR-T therapy for central nervous system tumors.
CAR-T 细胞疗法在中枢神经系统肿瘤中的应用已取得显著进展;
Safety and biological outcomes following a phase 1 trial of GD2-specific CAR-T cells in patients with GD2-positive metastatic melanoma and other solid
这是第三代GD2靶向CAR-T细胞在转移性黑色素瘤及其他实体癌(如结直肠癌)患者中的首次报告,显示了可行性、安全性和免疫活性,但临床效果有限。
Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression.
本研究利用无病毒基因组编辑技术生成具有TRAC靶向CAR的CAR T细胞,这可为制造用于治疗癌症(包括实体瘤)的CAR T细胞提供参考。
Targeting cancer stem cells with CAR-based immunotherapy: biology, evidence, and future directions.
癌症干细胞(CSCs)在肿瘤发生、进展和复发中起关键作用,凸显了靶向治疗以实现持久缓解的必要性。
CAR T-cell therapy landscape in pediatric, adolescent and young adult oncology - A comprehensive analysis of clinical trials.
我们的分析从最初40,690项研究中筛选出77项专门针对P-AYA人群的试验,筛选依据为年龄、日期以及与CAR T细胞干预在癌症治疗中相关的特定标准。
CAR T-Cell Therapy for Cancer: Latest Updates and Challenges, with a Focus on B-Lymphoid Malignancies and Selected Solid Tumours.
尽管如此,在标准治疗难治的晚期神经母细胞瘤中,抗GD2特异性CAR T细胞实现了60%的长期总生存率和63%的客观缓解率。
A Bibliometric and Knowledge-Map Analysis of CAR-T Cells From 2009 to 2021.
作为一种具有巨大潜力和临床应用前景的抗肿瘤疗法,CAR-T细胞疗法仍处于快速发展阶段。CAR-T细胞相关领域在未来仍将是研究热点。
Infectious complications of CAR T-cell therapy across novel antigen targets in the first 30 days.
我们提供了输注后30天内多种靶点和疾病感染风险的广泛概述,阐明了独特特征和共性,突出了对改善患者预后重要的方面。
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