下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
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Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy.
这些发现确立了可扩增GMP作为工程化免疫治疗的可扩展平台。
In vivo generation of CAR myeloid cells through erythrocyte-mediated mRNA delivery for cancer immunotherapy.
我们的研究建立了一个可临床转化的基于红细胞的 mRNA 平台,该平台能够实现直接的体内免疫细胞编程,并推动了针对实体瘤的 CAR 髓系疗法的发展。
IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers.
我们的工作表明,IDR 是通过诱导生物分子凝聚来改善 CAR-T 功能的新工具集。
Advances and challenges in CAR-T cell therapy for head and neck squamous cell carcinoma.
头颈部鳞状细胞癌(HNSCC)仍是最具侵袭性的恶性肿瘤之一,治疗选择有限,尤其是在复发和转移性病例中。
Advances in CAR-T therapy for central nervous system tumors.
CAR-T 细胞疗法在中枢神经系统肿瘤中的应用已取得显著进展;
CAR T cells: engineered immune cells to treat brain cancers and beyond.
恶性脑肿瘤属于治疗难度最大的恶性肿瘤类型。
Giant Cell Urothelial Carcinoma: Morphometric Insights and Associations With Aggressive Clinical Features.
我们报告了最大的GCUC系列,包括27例GCUC和27例匹配的对照尿路上皮癌(CoUC)患者,其中大多数(>90%)随访超过5年,包括新辅助和辅助治疗状态。
Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function.
这些数据共同揭示了对 CAR T 细胞代谢重编程的系统性认识,并揭示了改进 CAR T 细胞疗法的潜在靶点。
Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy.
PBMCs在新辅助治疗完成后表现出表型和功能的改变。在离体ADCC试验中,抗PD-1响应的PBMCs可能是治疗反应的生物标志物。
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