CELL INTELLIGENCE · 肿瘤细胞治疗研究

通过非病毒工程与高度多重碱基编辑精准增强 CAR-NK 细胞

Precision enhancement of CAR-NK cells through non-viral engineering and highly multiplexed base editing.

敲除 SMAD4 以拮抗 TGF-β 和激活素 A 抑制从而增强人 NK 细胞抗肿瘤功能

Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression.

将ζ缺失的 CAR 整合到 CD3ζ基因中可在 T 细胞和 NK 细胞中赋予强效细胞毒性

Integration of ζ-deficient CARs into the CD3ζ gene conveys potent cytotoxicity in T and NK cells.

CAR-T 细胞治疗在肿瘤免疫治疗中的应用——生物学、临床成功与新兴挑战：综述

CAR-T cell therapy in cancer immunotherapy - Biology, clinical successes, and emerging challenges: A review.

解析 MYC 介导的对传统抗体与 T 细胞重定向治疗性抗体的逃逸机制

Delineating MYC-Mediated Escape Mechanisms from Conventional and T Cell-Redirecting Therapeutic Antibodies.

HLA-A/B 和 TRAC 敲除的同种异体 CAR-T 细胞针对 B 细胞恶性肿瘤的有前景抗肿瘤能力

Allogeneic CAR-T cells with of HLA-A/B and TRAC disruption exhibit promising antitumor capacity against B cell malignancies.

nU-CAR-T19 细胞在 R/R B-ALL 中显示出强烈反应。nU-CAR-T19 细胞有潜力成为治疗 R/R B 细胞恶性肿瘤的一种有前景的新方法。

CRISPR 编辑 CAR-NK-92 细胞用于 AML 和 B-ALL 现货型治疗的临床前评价

Preclinical Evaluation of CRISPR-Edited CAR-NK-92 Cells for Off-the-Shelf Treatment of AML and B-ALL.

当前抗骨髓瘤 CAR-T 细胞：新型靶点与方法

Current Anti-Myeloma Chimeric Antigen Receptor-T Cells: Novel Targets and Methods.

肝细胞癌过继性细胞治疗的现状及开发“现货型”疗法的挑战

Current Landscape of Adoptive Cell Therapy and Challenge to Develop "Off-The-Shelf" Therapy for Hepatocellular Carcinoma.

CD45 敲除的 CD45 靶向 CAR-T 细胞即使经延长培养仍可在体外高效杀伤髓系白血病与淋巴瘤细胞

CD45-Directed CAR-T Cells with CD45 Knockout Efficiently Kill Myeloid Leukemia and Lymphoma Cells In Vitro Even after Extended Culture.

我们报道了高效且持久活性的 CD45 ko /CAR-T 细胞的高效制备。CD45 敲除并未损害 CAR-T 细胞的体外功能，无论靶抗原如何。如果其活性能在体内得到证实，CD45 ko /CD45CAR-T 细胞可能例如作为干细胞移植前预处理方案的组成部分而有用。