下一代 CAR-T 细胞疗法治疗实体恶性肿瘤演变过程中的近期进展与持续挑战:一项综合性综述
Recent advancements and persisting challenges in the evolution of next generation car t cell therapy for solid malignancies: a comprehensive review.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
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把在研试验和前沿论文合在一起看,按时间倒序排列。本页条数 = 前沿论文 + 临床试验两块之和(导航里的「临床试验」板块只收在招的那部分,不另计入)。
Recent advancements and persisting challenges in the evolution of next generation car t cell therapy for solid malignancies: a comprehensive review.
Metabolic and Post-Translational Vulnerabilities of Glioblastoma: Disulfidptosis, Glycosylation, and Implications for CAR-T Therapy.
CAR-T therapy in non-small cell lung cancer: Clinical prospects, potential, and strategies for cardiotoxicity management.
Challenges and breakthroughs: current landscape and future prospects of CAR-T cell therapy clinical trials for solid tumors.
CAR T cells in lung cancer: Targeting tumor-associated antigens to revolutionize immunotherapy.
GPC3/Mesothelin/Claudin18.2/GUCY2C/B7-H3/PSCA/PSMA/MUC1/TGFβ/HER2/Lewis-Y/AXL/EGFR-CAR-T Cells Against Cancers
这是一项 I 期注册临床试验,评估 Claudin18.2CAR-T 细胞治疗肺癌、恶性肿瘤、多发性骨髓瘤的安全性、可行性及初步疗效。当前状态:招募中。计划入组 30 例。试验地点:中国 · 广州(共 2 个中心,其中中国 2 个)。登记号:NCT03198052。
Advances in CAR T Cell Therapy for Non-Small Cell Lung Cancer.
Current progress in chimeric antigen receptor-modified T cells for the treatment of metastatic breast cancer.
Pan-Cancer Analysis Identifies Tumor Cell Surface Targets for CAR-T Cell Therapies and Antibody Drug Conjugates.
Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies
靶向 P329G 的 CAR-T 细胞联合含 P329G Fc 突变的人 IgG1 抗原结合抗体,在不同实体瘤模型中介导了显著的体外和体内效应功能,值得进一步推进该概念的临床转化。
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