IFNγ通过抗原特异性 T 细胞增强逃逸变异肿瘤细胞的铁死亡,从而控制异质性肿瘤
Enhancement of Ferroptosis in Escape Variant Tumor Cells by IFNγ Derived from Antigen-Specific T Cells Controls Tumor with Heterogeneity.
这些发现表明,将铁死亡诱导剂与免疫治疗相结合,可能克服逃逸变异肿瘤克隆所带来的限制,为癌症治疗提供一种有前景的策略。
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Enhancement of Ferroptosis in Escape Variant Tumor Cells by IFNγ Derived from Antigen-Specific T Cells Controls Tumor with Heterogeneity.
这些发现表明,将铁死亡诱导剂与免疫治疗相结合,可能克服逃逸变异肿瘤克隆所带来的限制,为癌症治疗提供一种有前景的策略。
All-In-One Magnetic Nanoparticles for Thermo-Immunotherapy of Malignant Melanoma.
本研究提供了一种可治愈恶性黑色素瘤的一体化磁性纳米颗粒的关键设计策略。
Immune evasion through mitochondrial transfer in the tumour microenvironment.
肿瘤微环境中的癌细胞利用多种机制逃避免疫系统的攻击,尤其是T细胞的攻击1。
Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment.
我们的研究为提高ALM免疫治疗的疗效提供了基础。
Blockade for CD276-mediated suppression of tumor-specific cytotoxic T lymphocytes may contribute to achieving durable responses with immune checkpoint
抑制CD276信号传导具有增强免疫检查点抑制剂长期治疗疗效的潜力。
Vaccination with a combination of STING agonist-loaded lipid nanoparticles and CpG-ODNs protects against lung metastasis via the induction of CD11b(hi
据目前所能确认,这是首次报道通过使用免疫治疗药物的预防性效应,在体内诱导、鉴定并确认记忆样NK细胞表型。我们的发现为体内诱导CD11b high CD27 low记忆样NK细胞提供了新的见解,从而为开发高效的免疫疗法铺平了道路。
TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment.
TIGIT/CD155轴介导TME炎症型黑色素瘤患者对ICIs的耐药,促进此类癌症患者中TIGIT阻断疗法的开发。
Cytokine Release Syndrome Induced by Combination Therapy With Nivolumab and Ipilimumab in Lower Palpebral Conjunctival Melanoma: A Case Report.
由免疫检查点抑制剂(ICIs)诱发的细胞因子释放综合征(CRS)是一种可能危及生命的免疫相关不良事件(irAE)。
A selective IDO1 inhibitor, KHK2455, improves efficacy of PD-L1 blockade by modulating both innate and adaptive immunity in a mouse melanoma model.
吲哚胺2,3-双加氧酶1(IDO1)通过将色氨酸分解代谢为犬尿氨酸(Kyn)促进肿瘤进展。
Phenotypic Analysis of 26 Cultured TILs Derived From Japanese Melanoma Tissues.
本研究首次对从一系列日本黑色素瘤患者中建立培养的TIL进行了特征描述。这些发现表明,从日本黑色素瘤组织中扩增肿瘤反应性TIL是可行的,并可能为日本TIL疗法的发展提供基础。
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