实体瘤的免疫细胞治疗:当前挑战与治疗进展
Immune cell-based therapies for solid tumors, current challenges and therapeutic advances.
实体瘤仍难以治疗,原因在于抗原异质性、限制免疫细胞迁移的物理屏障以及深度免疫抑制的肿瘤微环境(TME)。
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Immune cell-based therapies for solid tumors, current challenges and therapeutic advances.
实体瘤仍难以治疗,原因在于抗原异质性、限制免疫细胞迁移的物理屏障以及深度免疫抑制的肿瘤微环境(TME)。
Engineered immune cell therapies for solid tumors: pharmacological advances, clinical outcomes, and future directions.
实体肿瘤约占人类癌症的90%,由于抗原异质性、免疫抑制微环境以及常规药物治疗的可及性有限,其治疗面临独特挑战。
Checkpoint inhibition and beyond: Precision immune engineering for the immune-privileged landscape of ocular malignancies.
眼部恶性肿瘤,尤其是葡萄膜黑色素瘤和结膜黑色素瘤,正是肿瘤在人体免疫学限制最严苛的生态系统之一——眼部的免疫豁免微环境——中演进的典型例证。
Decoding NY-ESO-1 TCR T cells: transcriptomic insights reveal dual mechanisms of tumor targeting in a melanoma murine xenograft model.
我们的研究结果表明,NY-ESO-1 TCR 转导的 T 细胞有望通过抗原非依赖性的 NK 样反应和抗原特异性的 CTL 样反应介导双重抗肿瘤效应。
Harnessing antibody-mediated recognition of the intracellular proteome with T cell receptor-like specificity.
癌症免疫治疗的临床成功推动了持续的研究,以寻找能够有效引导强效效应功能清除恶性细胞的新靶点。
The Intracellular Proteome as a Source for Novel Targets in CAR-T and T-Cell Engagers-Based Immunotherapy.
肿瘤免疫治疗令人瞩目的临床成功,推动人们持续寻找新的靶点,以引导强效效应功能,从而高效杀伤恶性细胞。
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