细胞外 ATP-P2RY2 信号驱动瘤内前列腺素 E2 蓄积及实体瘤免疫治疗适应性耐药
Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors.
细胞外 ATP(eATP)在肿瘤微环境(TME)中蓄积,其代谢产物腺苷被认为可促进免疫抑制通路。
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Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors.
细胞外 ATP(eATP)在肿瘤微环境(TME)中蓄积,其代谢产物腺苷被认为可促进免疫抑制通路。
Harnessing the tumor microenvironment to boost adoptive T cell therapy with engineered lymphocytes for solid tumors.
使用嵌合抗原受体(CAR)和T细胞受体(TCR)工程化T细胞的过继细胞疗法(ACT)代表了一种治疗血液系统恶性肿瘤的创新性治疗手段,但其在实体瘤中的应用仍不理想。
TCR-engineered T cell therapy in solid tumors: State of the art and perspectives.
T 细胞工程改变了肿瘤免疫治疗的面貌。
Characterization of atypical T cells generated during ex vivo expansion process for T cell-based adoptive immunotherapy.
基于工程化 T 细胞的过继性免疫治疗在血液系统恶性肿瘤的治疗中取得了令人鼓舞的成功。
Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cells.
过去几年,过继性细胞疗法(ACT)在免疫肿瘤学研发管线中的新治疗策略数量急剧增加。
Tumour burden and antigen-specific T cell magnitude represent major parameters for clinical response to cancer vaccine and TCR-engineered T cell thera
我们提出,治疗性疫苗应考虑用于低或中等肿瘤负荷的情况,而Tg-T细胞策略可能更适合晚期转移性疾病的治疗。
Selection, engineering, and in vivo testing of a human leukocyte antigen-independent T-cell receptor recognizing human mesothelin.
HiT 可以从针对细胞表面表达抗原的全人 TCR 展示噬菌体库中分离得到。HiT 能够在体内和体外完全激活原代 T 细胞。HiT 可能使 pHLA 靶向 TCR 在实体瘤中观察到的疗效得以转化应用于细胞表面抗原。
Engineering a Dual Specificity γδ T-Cell Receptor for Cancer Immunotherapy.
γδ T细胞提供针对癌症的免疫监视,兼具固有免疫和适应性免疫的特性。
An IQ Consortium Perspective on Best Practices for Bioanalytical and Immunogenicity Assessment Aspects of CAR-T and TCR-T Cellular Therapies Developme
过去十年间,CAR-T 疗法在临床上对血液系统恶性肿瘤显示出显著疗效,新的研究表明,在将这些新型疗法用于靶向实体瘤以及治疗自身免疫性疾病方面正在取得进展。
Evolution by innovation as a driving force to improve TCR-T therapies.
过继细胞疗法通过基于科学的创新不断演进。
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