障碍与蓝图:胃肠道肿瘤 CAR-T 细胞治疗的下一代工程策略
Barriers and Blueprints: Next-Generation Engineering Strategies for CAR-T Cell Therapy in Gastrointestinal Tumors.
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Barriers and Blueprints: Next-Generation Engineering Strategies for CAR-T Cell Therapy in Gastrointestinal Tumors.
Claudin18.2 and the PD-1/PD-L1 axis in gastric cancer: mechanistic insights and implications for combination immunotherapy.
本综述提示,Claudin18.2 在胃癌中可能作为免疫功能障碍的关键调节因子,而非免疫排斥因子,为将 Claudin18.2 靶向治疗与免疫检查点抑制相联合的组合策略提供了潜在的生物学依据。
From Bench to Bedside: Emerging Paradigms in CAR-T Cell Therapy for Solid Malignancies.
Novel syngeneic model of anti-mouse CLDN18.2 CAR -T therapy for gastric cancer demonstrates a synergy with TGF-β and PD-L1 inhibitors.
GMP development and preclinical validation of CAR-T cells targeting a lytic EBV antigen for therapy of EBV-associated malignancies.
这些结果支持将用 ZT002 生成的 gp350CAR-T 细胞作为创新新药,用于治疗实体和血液 EBV 相关恶性肿瘤患者。
Interleukin-15 and chemokine ligand 19 enhance cytotoxic effects of chimeric antigen receptor T cells using zebrafish xenograft model of gastric cance
Progress in Adoptive Cell Therapy for Advanced Gastric Cancer.
New approaches of chimeric antigen receptor (CAR)-immune cell-based therapy in gastric cancer; highlight CAR-T and CAR-NK.
The Landscape of Clinical Trials for Claudin18.2-Positive Gastric Cancer.
CLDN18.2 已成为胃癌靶向治疗的重要新靶点。
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