肿瘤细胞治疗研究
英文原题：Progress in Adoptive Cell Therapy for Advanced Gastric Cancer.
尽管近年来胃癌的放疗、化疗和分子靶向治疗已取得巨大进展，但由于胃癌的高度异质性，胃癌患者的临床获益非常有限。
近年来，胃癌放疗、化疗和分子靶向治疗均取得很大进展，但由于胃癌高度异质性，患者获得的临床获益仍十分有限。随着对实体瘤免疫微环境和进展机制的研究不断深入，越来越多证据表明，过继性细胞转移疗法（ACT）作为一种新型精准治疗，在胃癌等实体瘤中具有重要临床应用潜力。CAR-T 细胞疗法、T 细胞受体工程化 T 细胞（TCR-T）疗法、自然杀伤（NK）细胞疗法等，可通过将特异性抗原识别组件与 T 细胞结合、对 T 细胞进行基因工程改造，以及在体外扩增并回输 NK 细胞等方式，抑制胃癌细胞增殖和转移；对不可切除和转移性胃癌患者尤其显示出较好治疗效果。本文回顾 ACT 的治疗原理、分类、主要靶点和当前治疗现状，并探讨其用于晚期胃癌精准治疗面临的机遇与挑战，旨在为胃癌临床治疗提供新思路。摘要后附重复且字符损坏的内容未另行翻译。
Although great progress has been achieved in radiotherapy,chemotherapy,and molecular targeted therapy for gastric cancer in recent years,the clinical benefits for patients with gastric cancer are very limited due to the high heterogeneity of gastric cancer.As the research on the immune microenvironment and the progression mechanism of solid cancers keeps advancing,accumulating evidence indicates that adoptive cell transfer therapy (ACT),as a novel precision therapy,holds important potential clinical applications in solid tumors such as gastric cancer.Chimeric antigen receptor T cell (CAR-T) therapy,T cell receptor-engineered T cell (TCR-T) therapy,natural killer (NK) cell therapy,etc.can inhibit the proliferation and metastasis of gastric cancer cells by conjugating specific antigen recognition components with T cells,genetically engineering T cells,and expanding and reinfusing NK cells in vitro .They exhibit particularly favorable therapeutic effects in patients with unresectable and metastatic gastric cancer.This article reviews the therapeutic principles,classification,main targets,and current treatment status of ACT and explores the opportunities and challenges it faces in the precision treatment of advanced gastric cancer,aiming to provide new ideas for the clinical treatment of gastric cancer. , , , , (ACT) , T (CAR-T) T (TCR-T) NK T T NK , ACT , , .
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