CELL INTELLIGENCE · 肿瘤细胞治疗研究

放射性药物通过肿瘤增敏与肿瘤微环境重塑增强 CAR-T 细胞对放射敏感及放射抵抗神经母细胞瘤的作用

A radiopharmaceutical enhances CAR T cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling.

CAR-T 细胞：改善儿童肿瘤结局所缺失的一环？

CAR T cells: the missing piece needed to improve outcomes for children with cancer?

展示靶抗原的细胞外囊泡增强神经母细胞瘤细胞和小鼠模型中 CAR-T 细胞疗效

Target antigen-displaying extracellular vesicles boost CAR T cell efficacy in cell and mouse models of neuroblastoma.

儿童和年轻成人原发性中枢神经系统肿瘤的 CAR-T 细胞疗法：早期临床试验的系统综述，重点关注弥漫性中线胶质瘤

Chimeric Antigen Receptor-T Cell Therapy for Pediatric and Young Adult Primary Central Nervous System Tumors: A Systematic Review of Early Phase Clini

初步临床经验表明，针对儿童和年轻成人 CNS 肿瘤的 CAR-T 细胞疗法具有生物学活性且临床可行，其毒性特征独特但可控。

靶向 GD2 的瞬时 mRNA CAR-T 细胞在弥漫性中线胶质瘤和高级别胶质瘤模型中提供剂量调整的疗效

Transient mRNA CAR T cells targeting GD2 provide dose-adjusted efficacy against diffuse midline glioma and high-grade glioma models.

我们的结果表明，瘤内递送的瞬时 mRNA CAR-T 细胞具有实用价值，能够以明确的半衰期提供有效的肿瘤杀伤，并允许对剂量和潜在副作用进行调控。

通过类似魔术贴的密度依赖性靶向肿瘤相关糖类抗原，实现安全且不受免疫抑制影响的泛癌免疫治疗

Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens.

无标记代谢成像监测 CAR-T 细胞的适应性

Label-free metabolic imaging monitors the fitness of chimeric antigen receptor T cells.

CAR-T 细胞治疗与外周实体瘤重建性肿瘤外科手术：叙述性综述

CAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors-A narrative review.

GD2 GD2T 细胞治疗胶质瘤：I 期临床试验（Baylor College of）

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

这是一项 I 期注册临床试验，评估 GD2T 细胞治疗胶质瘤的安全性、可行性及初步疗效。当前状态：招募中。计划入组 56 例。试验地点：美国 · 休斯顿（共 1 个中心）。登记号：NCT04099797。

放射性药物治疗产生的低剂量辐射增强 GD2 TRAC-CAR-T 细胞在局限性神经母细胞瘤中的疗效

Low-dose radiation by radiopharmaceutical therapy enhances GD2 TRAC-CAR T cell efficacy in localized neuroblastoma.