一种趋化因子"杠杆调控"仿生纳米制剂通过重塑免疫细胞生态位增强 CAR-T 细胞抗实体瘤作用
A chemokine "leverage regulation" biomimetic nanoformulation enhances CAR-T cells against solid tumors by reshaping immune cell niches.
驱动异常免疫细胞生态位的肿瘤趋化因子,在损害针对实体瘤的嵌合抗原受体(CAR)-T 细胞治疗中起关键作用。
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A chemokine "leverage regulation" biomimetic nanoformulation enhances CAR-T cells against solid tumors by reshaping immune cell niches.
驱动异常免疫细胞生态位的肿瘤趋化因子,在损害针对实体瘤的嵌合抗原受体(CAR)-T 细胞治疗中起关键作用。
A 3D engineered multiple myeloma niche for evaluating CAR T cell therapy.
我们的结果表明,该系统有效支持 MM 细胞的植入和 3D 聚集,同时成功模拟了肿瘤对成骨基质沉积的抑制作用。
Th17-driven CD8(+) T cells in hUC-MSC and CAR T-cell dual immunotherapy for superior anti-tumor efficacy.
我们的研究提供了一种新的治疗策略,以改善血液系统恶性肿瘤的临床结局。
Recent advances in CAR-MSCs: the new engine of cellular immunotherapy evolution.
近年来,嵌合抗原受体(CAR)技术的发展极大推动了细胞免疫治疗的进步。
Synthetic peptide hydrogels as a model of the bone marrow niche demonstrate efficacy of a combined CRISPR-CAR T-cell therapy for acute myeloid leukaem
白血病由造血干细胞(HSC)的突变驱动,其生长和存活依赖于与骨髓(BM)微环境以及其他细胞群体(如间充质基质细胞(MSC))的相互作用。
Tumor stroma and its role in therapy resistance: mechanisms and therapeutic opportunities.
靶向肿瘤基质通过改善药物递送、同时推进对肿瘤生物学和治疗耐药的理解,代表肿瘤学中一个有前景的方向,支持开发更有效、更具情境针对性的疗法。
A TIM-3-Fc decoy secreted by engineered T cells improves CD19 CAR T-cell therapy in B-cell acute lymphoblastic leukemia.
这些 TIM-3-Fc 诱饵装甲 CAR19 T 细胞为 R/R B-ALL 患者提供了一种有前景的治疗策略。
Construction and characterization of a novel secreted MsC-CAR-T cell in solid tumors.
CD47-SIRP 信号已被认为是重要的免疫检查点,阻断 CD47 已被证明是治疗实体瘤的一种潜在治疗策略。
Uncommon biphasic CAR-T expansion induces hemophagocytic lymphohistiocytosis-like syndrome and fatal multiple infections following BCMA CAR-T cell the
靶向 B 细胞成熟抗原(BCMA)的嵌合抗原受体(CAR)-T 细胞治疗显著改善了复发/难治性多发性骨髓瘤(MM)的治疗。
Pregnancy-specific glycoproteins as molecular links between mesenchymal stromal cells and M2 macrophages in tissue repair: implications for cancer pro
经过对间充质基质细胞(MSCs)数十年的研究,它们尚未在临床方案中常规使用。
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