骨肉瘤的基因免疫治疗:从溶瘤载体到工程化免疫细胞
Gene-based immunotherapy in osteosarcoma: from oncolytic vectors to engineered immune cells.
然而,免疫检查点阻断在未经选择的骨肉瘤患者中疗效有限:在SARC028研究中,22例接受pembrolizumab治疗的骨肉瘤患者中仅观察到1例客观缓解。
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Gene-based immunotherapy in osteosarcoma: from oncolytic vectors to engineered immune cells.
然而,免疫检查点阻断在未经选择的骨肉瘤患者中疗效有限:在SARC028研究中,22例接受pembrolizumab治疗的骨肉瘤患者中仅观察到1例客观缓解。
Oncolytic virus therapy for osteosarcoma: mechanisms, opportunities, and challenges.
已报道令人鼓舞的临床前证据:VSV-IFN-NIS在犬OS模型中实现了约35%的长期生存率,协同联合方案已显示出超过70%的肿瘤抑制率。
New insights into the mechanisms of the immune microenvironment and immunotherapy in osteosarcoma.
尽管手术和化疗提高了局限性病例的生存率,但肺转移使生存率显著降低至约20%,凸显了对新型治疗的需求。
The paradoxical role of stem cells in osteosarcoma: from pathogenesis to therapeutic breakthroughs.
骨肉瘤(OS)是青少年中最常见的原发性恶性骨肿瘤,具有高转移潜能和治疗耐药性。
Gene and Cell Therapy for Sarcomas: A Review.
背景:肉瘤的异质性及其由此产生的不同亚型特异性特征、高复发率和远处转移倾向,仍对提供最佳治疗构成重大挑战。
Galectin-3 inhibition boosts the therapeutic efficacy of Semliki Forest virus in pediatric osteosarcoma.
转移性和无应答的儿童骨肉瘤患者预后极差,在过去30年中未见改善。
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