分泌抗 CD73 scFv 的增强型 CD33 CAR-NK 细胞克服腺苷介导的免疫抑制并提高抗 AML 疗效
Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy.
CD33-CD73 双靶向 CAR-NK 平台协同靶向 AML 细胞和富含腺苷的肿瘤微环境,展现出更优的抗白血病疗效。
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Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy.
CD33-CD73 双靶向 CAR-NK 平台协同靶向 AML 细胞和富含腺苷的肿瘤微环境,展现出更优的抗白血病疗效。
Exploring CAR cell therapies beyond CAR-T for myeloid malignancies.
嵌合抗原受体(CAR)-T细胞在多种血液系统恶性肿瘤中已展现出显著疗效;
Progress in reprogramming failed graft-versus-leukemia immunity in acute myeloid leukemia relapse after allogeneic transplantation.
急性髓系白血病(AML)异基因造血干细胞移植(allo-HSCT)后复发影响40-50%的受者,并且仍然是移植后死亡的主要原因;中位总生存期约为5个月,1年生存率低于20%。
Engineering CLL-1 CAR-NK cells via mRNA-LNP for potent antitumor activity and reversal of HLA-E-mediated resistance in acute myeloid leukemia.
瞬时、非整合的 mRNA LNP 转染的 CLL-1 CAR-NK 细胞为 MDR AML 提供了一种安全有效的策略。
Beyond exhaustion: T cell fitness for next generation of immunotherapy for hematological cancer.
T细胞导向的免疫疗法已改变了血液系统恶性肿瘤的治疗,但持久获益仍受限于复发、持续性差、免疫重建不完全和感染。
Chronic ER Stress Triggers Cell-Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia.
这些结果提示,这些蛋白(尤其是在 FLT3-ITD + AML 细胞中)作为诊断标志物和治疗靶点具有巨大前景。
Clinical Trial of CD123-targeted CAR-NK Therapy for Relapse/Refractory AML or BPDCN
这是一项 I 期注册临床试验,评估 NK 细胞治疗急性髓系白血病、肿瘤的安全性、可行性及初步疗效。当前状态:招募中。计划入组 30 例。试验地点:中国 · 武汉(共 1 个中心,其中中国 1 个)。登记号:NCT06690827。
Tumor-priming CD8(+) natural killer T-like cells as an efficient novel cell therapy for relapsed/refractory multiple myeloma.
TPNC 是一种通过肿瘤驱动的致敏产生的新型细胞毒性淋巴细胞产品。
CD33(KO)-CD33-mesothelin Loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemia.
Loop CAR 赋予 UCB-NK 细胞和 hPSC-iNK 细胞更强的针对 CD33 + MSLN + 肿瘤细胞的细胞毒性。
CAR-NK's balancing act: when scFv affinity is not too tight, not too loose… but just right?
嵌合抗原受体 (CAR) 疗法使免疫细胞能够高特异性靶向肿瘤细胞,从而彻底改变了癌症治疗。
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