CELL INTELLIGENCE · 肿瘤细胞治疗研究

PDPN 与 GD2 双靶向增强 CAR-T 细胞对胶质母细胞瘤的疗效并促进持久肿瘤控制

Dual targeting of PDPN and GD2 enhances CAR T cell efficacy against glioblastoma and promotes durable tumor control.

FECH：影响 CAR-T 细胞表型与功能的新型代谢靶点

FECH, a novel metabolic target influencing CAR T-cell phenotype and function.

免疫基因组图谱揭示儿童脑肿瘤的基因治疗靶点

Immunogenomic profiling reveals targets for gene therapy in pediatric brain tumors.

这种整合分析方法识别出 pDMG 中可靶向的通路、表面抗原和新抗原，支持 CAR-T 和 TCR-T 疗法的开发。这些发现还提示其可能适用于其他携带相同突变的癌症。

胶质母细胞瘤的代谢与翻译后脆弱性：二硫死亡、糖基化及对 CAR-T 治疗的启示

Metabolic and Post-Translational Vulnerabilities of Glioblastoma: Disulfidptosis, Glycosylation, and Implications for CAR-T Therapy.

靶向 PDPN 与 GD2 的新型 CAR-T 细胞组合以克服胶质母细胞瘤异质性

Novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity.

这种新型 PDPN/GD2 CAR-T 细胞混合物在晚期临床前胶质母细胞瘤模型中显示出强效疗效，提示其具有治疗异质性胶质母细胞瘤和解决单抗原 CAR-T 细胞疗法相关局限性的潜力。

以溶瘤病毒增强 CAR-T 细胞功能用于治疗儿童弥漫性中线胶质瘤

Boosting CAR T cell functionality with oncolytic viruses for the treatment of pediatric diffuse midline gliomas.

人脑干类器官中 H3.3K27M 改变的弥漫性中线胶质瘤用于解析 GD2 CAR-T 细胞功能

De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell function.

靶向糖蛋白 GD2 的 CAR-T 细胞在高危室管膜瘤模型中显示强效抗肿瘤疗效

CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models.

肉瘤及其他实体瘤中的细胞治疗

Cellular therapies in sarcoma and other solid tumors.

CAR-T 细胞治疗神经系统肿瘤

CAR-T Cells in the Treatment of Nervous System Tumors.