PD-1 与 NKG2A 双重阻断预防 NK 细胞衰老并重编程胰腺癌免疫抑制微环境
Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer.
免疫检查点阻断 (ICB) 在胰腺导管腺癌 (PDAC) 中疗效有限。
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Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer.
免疫检查点阻断 (ICB) 在胰腺导管腺癌 (PDAC) 中疗效有限。
Dual targeting chimeric antigen receptor cells enhance antitumour activity by overcoming T cell exhaustion in pancreatic cancer.
尽管我们之前的数据表明,靶向claudin 18亚型2(CLDN18.2)的嵌合抗原受体(CAR)T细胞在CLDN18.2阳性胃癌中显示出显著的临床疗效,但其在胰腺导管腺癌(PDAC)中的疗效有限。
Orthotopic and Heterotopic Murine Models of Pancreatic Cancer Exhibit Different Immunological Microenvironments and Different Responses to Immunothera
本研究描述了通过植入组织切片构建新型原位 PDAC 模型,并从 PDAC 微环境的角度探讨了免疫治疗耐药。
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