CELL INTELLIGENCE · 肿瘤细胞治疗研究

一种为体内成像优化的新型无毛高度免疫缺陷小鼠模型

A novel hairless highly immunodeficient mice model optimized for in vivo imaging.

这种新型小鼠模型将成为无创肿瘤监测和抗癌疗效评估的宝贵工具。

高 CD73 表达通过减少基质 TIL（肿瘤浸润淋巴细胞）与胆道癌不良预后相关

High CD73 Expression Is Associated with Poor Prognosis in Biliary Tract Cancer Through Reduced Stromal Tumor-Infiltrating Lymphocytes.

组织驻留记忆 T 细胞浸润增加预示肝外胆管癌对抗 PD-L1 免疫治疗的良好反应

Increased Infiltration of Tissue-Resident Memory T Cells Predicts a Good Response to Anti-PD-L1 Immunotherapy in Extrahepatic Cholangiocarcinoma.

肿瘤内 CD8+和 CD103+ T 细胞可能作为 eCCA 中 ICI 疗效的预测生物标志物，突显组织驻留免疫细胞作为治疗靶点。

胆管癌中度伐利尤单抗联合吉西他滨和顺铂后行转化手术：一例病例报告

Conversion Surgery Performed Following Durvalumab Combined With Gemcitabine and Cisplatin in Cholangiocarcinoma: A Case Report.

CD103+ CD8+ T 细胞，最近被称为组织驻留记忆 T 细胞，可能是参与胆管癌中 ICI 诱导的抗癌免疫反应的关键免疫细胞群。

晚期肝内胆管癌联合免疫治疗成功治愈：聚焦肿瘤免疫微环境

Advanced intrahepatic cholangiocarcinoma successfully treated with combined immunotherapy: focusing on the tumor immune microenvironment.

Vδ2 γδ T 细胞和 NK 细胞对胆管癌细胞效应功能的分析

Analysis of the Effector Functions of Vδ2 γδ T Cells and NK Cells against Cholangiocarcinoma Cells.

曲妥珠单抗，一种抗 HER2 的单克隆抗体，通过多种机制调节对胆管癌的细胞毒性作用

Trastuzumab, a monoclonal anti-HER2 antibody modulates cytotoxicity against cholangiocarcinoma via multiple mechanisms.

肝内胆管癌中癌相关成纤维细胞衰老及其与 TIL（肿瘤浸润淋巴细胞）和 PD-L1 表达的关系

Cancer-associated fibroblast senescence and its relation with tumour-infiltrating lymphocytes and PD-L1 expressions in intrahepatic cholangiocarcinoma

以 CAV1 水平为代表的细胞衰老，可能是 CAF 的标志物，并通过 Foxp3+ TIL 调控成为 ICC 的预后指标。