更正：B7-H3 CAR T 细胞清除肝内胆管癌并诱导持久应答
Correction: B7-H3 CAR T cells eradicate intrahepatic cholangiocarcinoma and induce durable response.
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CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
晚期肝内胆管癌联合免疫治疗成功治愈：聚焦肿瘤免疫微环境
英文原题：Advanced intrahepatic cholangiocarcinoma successfully treated with combined immunotherapy: focusing on the tumor immune microenvironment.
研究概要
一名61岁女性患者，根据影像学和肿瘤活检结果诊断为晚期肝内胆管癌，接受吉西他滨、顺铂和度伐利尤单抗联合治疗。
中文摘要
一名61岁女性患者，根据影像学和肿瘤活检结果诊断为晚期肝内胆管癌，接受吉西他滨、顺铂和度伐利尤单抗联合治疗。在完成八周期吉西他滨、顺铂和度伐利尤单抗治疗及随后两周期维持免疫治疗后，肿瘤显著缩小，使转化手术得以实现R0切除。肿瘤免疫微环境在某些类型癌症中对于预测联合免疫治疗疗效具有关键作用；然而，其在晚期肝内胆管癌中的作用仍 largely 不明确。在本病例中，肿瘤在治疗前表现出CD8 T细胞浸润增加，治疗后观察到CD8 T细胞浸润显著增加、Treg/CD8比值下降以及三级淋巴结构形成。治疗前肿瘤免疫微环境分析可能预测治疗结局并优化晚期肝内胆管癌的治疗策略。吉西他滨、顺铂和度伐利尤单抗联合治疗及基于免疫的方法可能促进晚期肝内胆管癌患者的个性化医疗。
展开英文摘要原文
A 61-year-old female patient with advanced intrahepatic cholangiocarcinoma diagnosed based on imaging and tumor biopsy findings was treated with combination therapy comprising gemcitabine, cisplatin, and durvalumab. After eight cycles of therapy comprising gemcitabine, cisplatin, and durvalumab and two subsequent cycles of maintenance immunotherapy, significant tumor shrinkage enabled conversion surgery with R0 resection. The tumor immune microenvironment has a critical role in predicting the efficacy of combined immunotherapy in some types of cancer; however, its role in advanced intrahepatic cholangiocarcinoma remains largely unclear. In the current case, the tumor exhibited increased infiltration of CD8 T cells before treatment, and significant increase in CD8 T-cell infiltration, decrease in Treg/CD8 ratio, and development of tertiary lymphoid structures were observed after treatment. Pretreatment tumor immune microenvironment analyses may predict treatment outcomes and optimize strategies for advanced intrahepatic cholangiocarcinoma. Therapy comprising gemcitabine, cisplatin, and durvalumab and immune-based approaches may enhance personalized medicine for patients with advanced intrahepatic cholangiocarcinoma.
论文信息
- 作者
- Omoto M、Sugimoto K、Kurebayashi Y、Kakegawa T、Takahashi H、Wada T、Takeuchi H、Nagao T
- 第一作者单位
- Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 1600023, Japan.Japan
- 通讯作者单位
- Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 1600023, Japan. sugimoto@tokyo-med.ac.jp.Japan
- 文献类型
- 病例报告
- 期刊
- Clinical journal of gastroenterology2025 Jun
- 原文标识
- PubMed 40153223 · DOI 10.1007/s12328-025-02113-2