肿瘤细胞治疗研究
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Engineered Natural Killer Cell Derived-Extracellular Vesicles: An Acellular Immunotherapy with Cytotoxic Effects in SNU-1079 Human Cholangiocarcinoma
自然杀伤（NK）细胞用于治疗胆管癌等实体瘤，一直受到细胞生产、持久性和 trafficking 方面的挑战，以及免疫抑制性肿瘤微环境中疗效降低的阻碍。
Selective Internal Radiotherapy Changes the Immune Profiles of Extracellular Vesicles and Their Immune Origin in Patients with Inoperable Cholangiocar
胆管细胞癌（CCA）的发病率在全球范围内呈上升趋势。
Mesenchymal stem cell‑derived exosomes loaded with 5‑Fu against cholangiocarcinoma in vitro.
与游离5 Fu组相比，5 Fu Exos组显著抑制了CCA细胞的活力（P<0.01），表明5 Fu Exos可作为CCA治疗的有效化疗药物。
Cholangiocarcinoma derived exosomes attenuate the anti-tumor functions of NK cells.
本研究表明，胆管癌可能通过外泌体从多方面抑制NK细胞功能，从而逃避免疫监视。
Chitosan hydrogel incorporated with bone marrow mesenchymal stem cell-derived exosomal TIMP2 to inhibit angiogenesis in cholangiocarcinoma.
该研究验证了 BMSC-Exo/CS TIMP2 在 CCA 治疗中的治疗潜力。
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