肿瘤细胞治疗研究
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Tumor Inflammation-Associated Neurotoxicity Masquerading as Severe Immune Effector Cell-Associated Neurotoxicity Syndrome in a Patient With SCLC Treat
在接受tarlatamab治疗的SCLC伴脑转移患者中，严重急性神经毒性可能提示TIAN。TIAN表现为严重但可逆的症状，类似高级别ICANS。区分TIAN与ICANS至关重要，因为TIAN可能可控，识别TIAN有助于在密切监测下个体化决定是否继续治疗。
Development and optimization of Eva1 (MPZL2) targeting chimeric antigen receptor T cells.
这些数据表明，人源化 Eva1CAR-T 在治疗多种 Eva1 阳性实体瘤方面具有有前景的治疗潜力。
NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors.
NR4A因子通过线粒体基因表达调控CAR-T细胞的持久性和干性，因此NR4A是生成针对实体瘤的优质CAR-T细胞的高度有前景的靶点。
Human iPSC-derived NK cells armed with CCL19, CCR2B, high-affinity CD16, IL-15, and NKG2D complex enhance anti-solid tumor activity.
这些概念验证研究表明，我们的 eNK 细胞作为一种用于治疗实体瘤的新型过继性细胞疗法产品具有前景。
Bispecific Ligand-Based EphB4 CAR-T Cells Generated Using Ephrin-B2 Show Potent Antitumor Activity Against Lung Adenocarcinoma.
基于配体的EphB4 CAR-T细胞是双特异性的，同时靶向EphB4和EphA2。
Mechanisms of resistance to antibody-drug conjugates in cancers.
近年来，随着分子靶向药物、单克隆抗体、免疫检查点抑制剂、双特异性抗体和CAR-T 细胞疗法等多种治疗模式的出现，癌症治疗取得了巨大进展。
Tocilizumab for Steroid Pulse-Refractory Cytokine Release Syndrome in Chemotherapy With Durvalumab Plus Tremelimumab for NSCLC: A Case Report.
免疫检查点抑制剂显著改善了NSCLC的预后。
CD98 heavy chain protein is overexpressed in non-small cell lung cancer and is a potential target for CAR T-cell therapy.
这些结果提示，R8H283 CAR T 细胞可能成为 NSCLC 的新治疗工具，尽管未来应仔细检测肿瘤外反应性。
Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer.
未标注：小细胞肺癌（SCLC）极具侵袭性，治疗选择有限。
Efficacy against Lung Cancer Is Augmented by Combining Aberrantly N-Glycosylated T Cells with a Chimeric Antigen Receptor Targeting Fragile X Mental R
通过嵌合Ag受体（CAR）将T细胞重定向至癌细胞的适应性转移已为血液病的治疗产生了临床获益。
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