CELL INTELLIGENCE · 肿瘤细胞治疗研究

衰老相关泛癌多组学的临床转化：评估与免疫治疗预测工具

Clinical translation of senescence-related pan-cancer multi-omics: tools for assessment and immunotherapy prediction.

烟酰胺单核苷酸增强靶向 MSLN 的 CAR-NK 细胞治疗在卵巢癌中的抗肿瘤疗效

Nicotinamide mononucleotide potentiates the anti-tumor efficacy of CAR-NK cell therapy targeting MSLN in ovarian cancer.

胶质瘤中肿瘤来源的 LAIR-1 通过双重机制驱动纤维化并阻断免疫细胞招募，导致癌症免疫排斥

A dual pronged approach to cancer immune exclusion: tumor-derived LAIR-1 simultaneously drives fibrosis and blocks immune recruitment in glioma.

加速 NK 细胞疗法向临床转化：欧洲视角

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective.

免疫基因组图谱揭示儿童脑肿瘤的基因治疗靶点

Immunogenomic profiling reveals targets for gene therapy in pediatric brain tumors.

这种整合分析方法识别出 pDMG 中可靶向的通路、表面抗原和新抗原，支持 CAR-T 和 TCR-T 疗法的开发。这些发现还提示其可能适用于其他携带相同突变的癌症。

HSVtk 和 IL-15Rα武装的痘苗病毒诱导系统性抗肿瘤免疫的协同溶瘤效应

Synergistic Oncolytic Effect of HSVtk- and IL-15Rα-Armed Vaccinia Viruses Inducing Systemic Antitumor Immunity.

ROBO1 CAR-NK92 细胞中 Cbl-b 敲除增强其抗肿瘤疗效

Ablation of Cbl-b in ROBO1 CAR-NK92 Cells Enhances Their Antitumor Efficacy.

通过瘤内核苷裂解拓宽检查点阻断剂的活性

Broadening activity of checkpoint blockade agents by intratumoral nucleoside cleavage.

头颈部鳞状细胞癌中的 SPTSSA：预后意义及对基因和细胞治疗的意义

SPTSSA in Head and Neck Squamous Cell Carcinoma: Prognostic Significance and Implications for Gene- and Cell-Based Therapy.

研究发现确立了 SPTSSA 是 HNSCC 中的关键致癌驱动因子，其上调与 TME 免疫重塑及患者不良预后密切相关。这些结果拓展了 HNSCC 的致癌图谱，并与 SPTSSA 在其他恶性肿瘤中的促肿瘤作用相一致。循环 SPTSSA 升高为早期检测提供了一种非侵入性诊断工具，而其与免疫细胞浸润的相关性使 SPTSSA 成为 HNSCC 免疫治疗中有前景的分子靶点。SPTSSA 是一个驱动 HNSCC 进展的致癌基因，并与患者不良预后密切

CAR-NK 细胞作为 T 细胞相关疾病体外疗法的潜在应用

Potential Application of CAR-NK Cells as an Ex Vivo Therapy for T-cell-related Diseases.