CELL INTELLIGENCE · 肿瘤细胞治疗研究

靶向由多种 HLA-II 等位基因混杂呈递的胞内白血病抗原的 CAR-T 细胞

CAR T Cells Targeting an Intracellular Leukemia Antigen Promiscuously Presented by Diverse HLA-II Alleles.

用 TCR 模拟抗体工程化 T 细胞进行三特异性靶向以限制抗原逃逸

Trispecific targeting of T cells engineered with TCR mimic antibodies to limit antigen escape.

靶向 WT1 肽/HLA-A2 复合物的免疫蛋白酶体依赖性和非依赖性表位的三特异性 T 细胞，加上识别第三种肿瘤相关抗原的 CSR，提供了一种有效且经济高效的方法来克服肿瘤免疫逃逸。

一项针对异基因造血细胞移植后患有活动性疾病的急性髓系白血病患者的 WT1 特异性 TCR 基因治疗的 I/II 期试验：向 NK 样表型偏移损害 T 细胞功能和持续性

A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell tra

急性髓系白血病使治疗性 WT1 特异性 CD8 TCR-T 细胞偏向 NK 样表型，损害其功能与持久性

Acute Myeloid Leukemia Skews Therapeutic WT1-specific CD8 TCR-T Cells Towards an NK-like Phenotype that Compromises Function and Persistence.

携带 Ab-TCR 与共刺激受体的双受体 T 细胞平台实现对 AML 的特异性与效力

A dual-receptor T-cell platform with Ab-TCR and costimulatory receptor achieves specificity and potency against AML.

靶向替代性 Wilms 瘤抗原 1 肽绕过免疫蛋白酶体依赖性

Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.